spec sheet10 rows
Salvinorin B methoxymethyl ether (MOM-Salvinorin B) is a semi-synthetic analog of salvinorin A, the active diterpene of the plant Salvia divinorum. Like its parent it is a potent and selective kappa-opioid receptor agonist, a mechanism distinct from the 5-HT2A pathway of classic psychedelics; the receptor basis of salvinorin action has been confirmed in humans, where its subjective and physiological effects are blocked by the opioid antagonist naltrexone but not by the serotonin-2A antagonist ketanserin. In drug-discrimination studies MOM-Salvinorin B fully substitutes for salvinorin A while showing greater potency and a longer duration of action. The kappa agonism produces an intense, disorienting, and often dysphoric dissociative-psychedelic state accompanied by marked reductions in cortical blood flow, and the compound shares the atypical, difficult-to-control character of salvinorin A.
- Intense short-form psychedelic experience
- Novel kappa-opioid pharmacology of research interest
- Non-serotonergic mechanism
- Longer-acting, more potent kappa-opioid agonist
- Frightening, disorienting dissociation
- Loss of bodily control and risk of injury
- Confusion and amnesia of the experience
- Longer, harder-to-abort effects than salvia
Mechanism
This compound is a modified salvinorin, and like salvinorin A it acts as a selective at the kappa-opioid receptor rather than the classic pathway used by most psychedelics. Kappa-opioid activation produces the characteristic salvia experience: profound dissociation, distorted sense of body and space, and vivid, often unsettling alterations of reality. The methoxymethyl ether modification changes its metabolism and duration, and it is presumed to retain the kappa-agonist mechanism of the parent while acting somewhat longer.
receptor fingerprint
Kappa-opioid receptor (KOR)Agonist
Safetyrisks and cautions, not medical advice
Kappa-opioid agonists like this produce an intense, disorienting state that can be genuinely frightening and comes on fast, so a sober sitter and a safe, seated setting matter; people can hurt themselves by moving or falling while disconnected from reality. Because this analog is longer-lasting than salvinorin A, a difficult experience can drag on. It is poorly studied in humans, so purity and potency are uncertain. Not medical advice.
Subjective profileweighing the evidence above
Harder and longer than salvia with no gain to show for it. Kappa agonism produces a fast, disorienting state people routinely find frightening and often cannot remember afterwards, and the injury risk from losing bodily control is physical and real. Barely studied in humans. Not worth it.
Resources
No suppliers are provided for compounds like this. This entry is here for reference.
Research
- 2009first citedComparison of the discriminative stimulus effects of salvinorin A and its derivatives to U69,59…
- 2012controlled trialDose-related behavioral, subjective, endocrine, and psychophysiological effects of the κ opioid…
- 2022most recentThe Kappa Opioid Receptor and the Sleep of Reason: Cortico-Subcortical Imbalance Following Salv…
- 1.Synthesis and biological evaluation of 2-alkyl-2-methoxymethyl-salvinorin ethers as selective κ-opioid receptor agonists
- 2.Dose-related behavioral, subjective, endocrine, and psychophysiological effects of the κ opioid agonist Salvinorin A in humans
- 3.Salvinorin B derivatives, EOM-Sal B and MOM-Sal B, produce stimulus generalization in male Sprague-Dawley rats trained to discriminate salvinorin A.
- 4.Comparison of the discriminative stimulus effects of salvinorin A and its derivatives to U69,593 and U50,488 in rats.
- 5.Naltrexone but Not Ketanserin Antagonizes the Subjective, Cardiovascular, and Neuroendocrine Effects of Salvinorin-A in Humans.
- 6.The Kappa Opioid Receptor and the Sleep of Reason: Cortico-Subcortical Imbalance Following Salvinorin-A.
6 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is this different from salvinorin A?
It is a chemically modified version (an ether) of a salvinorin, presumed to share the kappa-opioid mechanism but reported to last longer, which can make a bad experience harder to ride out.
Is it an opioid like heroin?
It acts at a different opioid receptor, the kappa type, which does not produce classic opioid euphoria or respiratory depression; instead it causes an intense dissociative-psychedelic state.
Why do people find salvia-type effects so intense?
Kappa-opioid activation can rapidly dissolve the normal sense of self, body and surroundings, which many people describe as overwhelming and frightening rather than pleasant.
Adverse effects
- Frightening, disorienting dissociation
- Loss of bodily control and risk of injury
- Confusion and amnesia of the experience
- Longer, harder-to-abort effects than salvia