3-HO-PCP

3-HO-PCP (3-hydroxyphencyclidine) is a hydroxylated analog of phencyclidine that acts as an NMDA receptor antagonist and, unusually for a dissociative, also displays notable mu-opioid receptor activity arising from its 3-hydroxy group; it is reported to be more potent than PCP itself. This dual mechanism can add opioid-like sedation and respiratory risk to the expected dissociative effects. Analytically confirmed case reports document severe toxicity, including hyperthermia, tachycardia, rhabdomyolysis, and serotonergic features, and forensic studies have quantified the drug and mapped its hepatic metabolism, noting brain concentrations exceeding those in blood. In silico work flags moderate acute toxicity and potential cardiotoxicity, while controlled human data remain absent.