spec sheet10 rows
O-PCE (eticyclidone, 2-oxo-PCE) is a ketone-bearing arylcyclohexylamine of the eticyclidine family, structurally related to deschloroketamine and the PCE dissociatives. It is presumed to act as an NMDA-receptor antagonist, the mechanism shared across the phencyclidine and ketamine classes, and user reports describe it as relatively potent with a notably stimulating dissociative character. It remains an obscure research chemical with essentially no dedicated pharmacological or clinical study; the available literature is confined to forensic and analytical work in which O-PCE has been detected in authentic hair samples and its metabolism inferred alongside the closely related derivative 3-hydroxyeticyclidine. Human safety and dosing data are correspondingly limited.
- Potent dissociation
- Stimulating headspace
- Euphoria at lower doses
- Potent stimulating arylcyclohexylamine NMDA antagonist dissociative
- Confusion and agitation
- Impaired coordination
Mechanism
It is presumed to antagonize the receptor like other arylcyclohexylamines, reducing excitatory glutamate signaling to produce dissociation. Structurally it resembles ketamine-type compounds with a PCE-style side chain, which is thought to give it a somewhat more stimulating, potent character; human affinity data are limited.
receptor fingerprint
Antagonist
Safetyrisks and cautions, not medical advice
As a potent dissociative it strongly impairs coordination and judgment and can produce a dissociative state, confusion, and agitation at higher doses, with a risk of falls and reckless behavior. Human data are sparse, so potency and margin are uncertain and redosing can compound effects. It is dangerous combined with other depressants such as alcohol, benzodiazepines, or opioids. Not medical advice.
Subjective profileweighing the evidence above
A potent dissociative with essentially no pharmacological study behind it, so the gap between an interesting dose and a confused, badly uncoordinated one is not mapped. Combining it with alcohol, benzodiazepines or opioids is the genuinely dangerous part.
Resources
This entry is here for reference.
Research
- 2021first citedMetabolic profiling of deschloro-N-ethyl-ketamine and identification of new target metabolites…
- 2024most recentA combined toxicokinetic and metabolic approach to investigate deschloro-N-ethylketamine exposu…
- 1.Metabolic profiling of deschloro-N-ethyl-ketamine and identification of new target metabolites in urine and hair using human liver microsomes and high-resolution accurate mass spectrometry
- 2.A combined toxicokinetic and metabolic approach to investigate deschloro-N-ethylketamine exposure in a multidrug user
- 3.Hair-based rapid UPLC-MS/MS analysis of 36 phencyclidine-type substances in forensic cases.
- 4.Characterization of 3-Hydroxyeticyclidine (3-HO-PCE) Metabolism in Human Liver Microsomes and Biological Samples Using High-Resolution Mass Spectrometry.
4 listed here; entry last updated July 2026
Reviews
My notesprivate to this device
FAQ
Is O-PCE the same as deschloroketamine?
They are close relatives in the same family, but O-PCE has a PCE-style side chain and is reported to be more stimulating.
How potent is it?
It is reported to be fairly potent, so small dosing errors can have outsized effects.
Is it well studied?
No. It is an obscure analog with limited human data, so its risks are not fully mapped.
Adverse effects
- Confusion and agitation
- Impaired coordination
Notes and cautions
- Compulsive redosing
- Unknown safety margin