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3-MeO-PCE (3-methoxyeticyclidine) is a methoxylated analog of eticyclidine (PCE) in the arylcyclohexylamine class that acts as an NMDA receptor antagonist, reportedly with higher NMDA receptor binding affinity than phencyclidine itself. Positioned within the PCP/PCE family, it tends to be more stimulating and disinhibiting than ketamine and has been implicated in fatal intoxications, typically in combination with other substances. Its in vitro and in vivo metabolism has been mapped in human liver microsomes, a zebrafish model, and authentic urine samples, proceeding through hydroxylation, O-demethylation, and N-dealkylation, with a hydroxylated metabolite proposed as a biomarker of use. It remains an obscure research chemical with limited controlled human data.
- Dissociation
- Stimulating headspace
- Euphoria at lower doses
- Higher NMDA affinity than phencyclidine
- Confusion and agitation
Mechanism
It is presumed to block the receptor like other arylcyclohexylamines, reducing excitatory signaling to produce dissociation. The PCE/PCP backbone is associated with a more stimulating, disorganizing character than ketamine, possibly via additional monoamine effects, though data for this specific analog are limited.
receptor fingerprint
Antagonist
Safetyrisks and cautions, not medical advice
PCE-type dissociatives can bring confusion, agitation, mania-like states, and impaired judgment, with real risk of injury or reckless behavior; effects can also be long and unpredictable. Human data are sparse, so potency and margin are uncertain. It is dangerous combined with other depressants or stimulants. Not medical advice.
Subjective profileweighing the evidence above
Not worth it. It binds NMDA harder than PCP, runs stimulating and disorganizing rather than calm, and has been implicated in fatal intoxications; human data is too thin to know where the margin even sits.
Resources
This entry is here for reference.
Research
- 2013first citedThe ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high af…
- 2026most recentQualitative and quantitative in silico toxicity profiling of "angel dust": phencyclidine (PCP)…
- 1.The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor.
- 2.Methoxetamine--a novel recreational drug with potent hallucinogenic properties.
- 3.In vitro and in vivo metabolism of 3-Methoxyeticyclidine in human liver microsomes, a zebrafish model, and two human urine samples based on liquid chromatography-high-resolution mass spectrometry.
- 4.Fatal intoxication related to two new arylcyclohexylamine derivatives (2F-DCK and 3-MeO-PCE).
- 5.From the street to the laboratory: analytical profiles of methoxetamine, 3-methoxyeticyclidine and 3-methoxyphencyclidine and their determination in three biological matrices.
- 6.Syntheses and analytical characterizations of N-alkyl-arylcyclohexylamines.
- 7.Qualitative and quantitative in silico toxicity profiling of "angel dust": phencyclidine (PCP) analogues as new psychoactive substances (3-HO-PCP, 3-MeO-PCP, 4-MeO-PCP, 3-HO-PCE, 3-MeO-PCE, 4-MeO-PCE).
7 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How does 3-MeO-PCE compare to ketamine?
It is more stimulating and disinhibiting, with a greater tendency toward confusion or manic states, especially at higher doses.
Is it well studied?
No. It is an obscure analog with little human safety data, so its risks are not well defined.
Why is redosing a concern?
Dissociatives can feel compelling to repeat, and stacking doses deepens disorientation and unpredictability.
Adverse effects
- Confusion and agitation
Notes and cautions
- Mania-like states at high doses
- Impaired judgment
- Compulsive redosing