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3-Cl-PCP (3-chlorophencyclidine) is a ring-substituted analog of phencyclidine presumed to act, like its parent, as an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. In rodent studies it fully substitutes for PCP in drug discrimination and produces marked locomotor stimulation alongside psychosis-like neurocognitive deficits in tasks assessing rule-governed behavior, a profile not observed with cocaine or morphine. Human data are limited to forensic case work; a fatal intoxication has been characterized analytically, with phase I metabolism proceeding largely through hydroxylation of the cyclohexyl and piperidine rings followed by glucuronidation. It remains an obscure research chemical for which controlled human pharmacology is lacking, warranting caution.
- Dissociation
- Stimulating, disinhibited headspace
- Chlorinated PCP analog; PCP-like NMDA dissociative
- Confusion and agitation
- Impaired judgment and injury risk
- Possible cardiovascular strain
Mechanism
It is presumed to act, like PCP, as an at the receptor, blocking excitatory signaling to produce dissociation. PCP-class compounds may also touch and sigma systems, which is thought to contribute to their more stimulating and disorganizing character; precise data for this analog are lacking.
receptor fingerprint
Antagonist
Safetyrisks and cautions, not medical advice
PCP-type dissociatives can produce marked confusion, agitation, and impaired judgment, with a risk of injury, dangerous behavior, and prolonged effects that are hard to predict. Because human data on 3-Cl-PCP are minimal, dosing is guesswork and the margin is unknown. It is dangerous combined with other depressants or stimulants, and high doses can bring on delirium and cardiovascular strain. Not medical advice.
Subjective profileweighing the evidence above
Hard pass. A fatal intoxication has already been documented, rodent work shows psychosis-like impairment on top of the dissociation, and there is no human pharmacology at all, so dosing is pure guesswork. Nothing it offers justifies that.
Resources
This entry is here for reference.
Research
- 1.Phase I Metabolism of Novel Phencyclidine Derivative 3-Cl-PCP: In Vitro Studies With Pooled Human Liver Microsomes and Investigation of a Post-Mortem Case
- 2.Phencyclidine-Like Abuse Liability and Psychosis-Like Neurocognitive Effects of Novel Arylcyclohexylamine Drugs of Abuse in Rodents
2 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is it different from ketamine?
PCP-type dissociatives are usually longer and more disinhibiting, with more confusion and agitation than ketamine.
Is there much human data?
No. It is an obscure analog with very little documented human experience, so its risks are poorly mapped.
Why is the long duration a concern?
Effects can outlast expectations, leaving someone impaired and disoriented for an extended and unpredictable time.
Adverse effects
- Confusion and agitation
- Impaired judgment and injury risk
- Possible cardiovascular strain
Notes and cautions
- Unpredictable long duration