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Lisuride is an ergoline (ergot-derived) drug that acts as a dopamine D2-like receptor agonist while also blocking the 5-HT2B serotonin receptor. It is used medically for Parkinson's disease and for prolactin-related disorders, and unlike some related ergolines it is non-hallucinogenic at therapeutic use. Its character is that of a dopamine agonist with a favorable serotonin-receptor profile compared with older ergots.
- Effective dopamine agonist for Parkinson's
- Lowers elevated prolactin
- Non-hallucinogenic in therapeutic use
- 5-HT2B blockade favors cardiac safety versus older ergots
- Nausea and low blood pressure
- Drowsiness and dizziness
- Impulse-control effects from dopamine agonism
- Ergot-class cautions
Mechanism
Lisuride stimulates -like receptors, which is why it helps in Parkinson's disease (replacing lost dopamine signaling) and lowers prolactin (dopamine normally suppresses prolactin release from the pituitary). It is also a potent at the 5-HT2B receptor, and this matters because 5-HT2B activation is linked to the heart-valve fibrosis seen with some other ergot dopamine agonists; blocking it is thought to make lisuride's cardiac profile more favorable. Although it interacts with receptors, in humans it behaves as a non-hallucinogenic agent, functioning as a functional antagonist at that pathway rather than a psychedelic . The overall picture is a mixed dopamine/serotonin receptor drug tuned toward dopaminergic therapy.
receptor fingerprint
-like receptorsagonist
5-HT2B receptorantagonist
receptorfunctional antagonist
Dosingtypical ranges, not medical advice
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Safetyrisks and cautions, not medical advice
As an ergoline and a real prescription drug, lisuride can cause nausea, low blood pressure and dizziness, drowsiness, and dopaminergic side effects such as impulse-control problems, and it must be used under medical supervision. Combining it with other dopaminergic or serotonergic drugs is risky, and abrupt changes can worsen symptoms. It is a serious medication, not a nootropic to experiment with. Not medical advice.
Subjective profileweighing the evidence above
A real prescription drug with a genuine edge over the older ergots, since its 5-HT2B blockade favors cardiac safety instead of threatening it. Impulse-control problems come with the territory of dopamine agonism, and this belongs under a neurologist rather than in a nootropic stack.
Resources
This entry is here for reference.
Research
- 1.Lisuride, a dopamine receptor agonist with 5-HT2B receptor antagonist properties: absence of cardiac valvulopathy adverse drug reaction reports supports the concept of a crucial role for 5-HT2B receptor agonism in cardiac valvular fibrosis.
- 2.Function and expression differences between ergot and non-ergot dopamine D2 agonists on heart valve interstitial cells.
2 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
Is lisuride hallucinogenic since it's an ergoline?
No; despite touching serotonin receptors, at therapeutic use it behaves as a non-hallucinogenic dopamine agonist.
Why does it block 5-HT2B?
5-HT2B activation is linked to heart-valve fibrosis with some ergot agonists, so blocking it is thought to give lisuride a more favorable cardiac profile.
What is it prescribed for?
Mainly Parkinson's disease and prolactin-related disorders, always under medical supervision.
Adverse effects
- Nausea and low blood pressure
- Drowsiness and dizziness
- Impulse-control effects from dopamine agonism
- Ergot-class cautions