data + articles · 6 listed
newest 2023spec sheet10 rows
5-MAPB (N-methyl-5-(2-aminopropyl)benzofuran) is the N-methyl homolog of 5-APB, standing in the same relationship to it as MDMA does to MDA. It is a benzofuran entactogen that acts as a substrate-type releaser of serotonin, dopamine, and norepinephrine with nanomolar potency, producing warmth, empathy, and stimulation, and in drug-discrimination studies it fully substitutes for MDMA while being more potent, consistent with MDMA-like subjective effects and abuse liability. It is often described as smoother and more MDMA-like than 5-APB. Metabolism proceeds mainly by CYP-mediated N-demethylation, chiefly via CYP2B6, yielding 5-APB as a major metabolite; like other benzofurans it carries the family's specific concern over 5-HT2B receptor agonism and associated cardiac-valve risk in addition to the usual entactogen hazards.
- Empathy and warmth
- Stimulation and energy
- Mood elevation
- Often described as smoother than 5-APB
- MDMA-like benzofuran releaser; substitutes for MDMA
- Overheating (hyperthermia)
- Cardiovascular strain
Mechanism
5-MAPB acts as a releasing agent and at the , , and transporters, elevating all three monoamines to drive entactogenic and stimulant effects. Like other benzofurans it is presumed to retain activity at the 5-HT2B receptor; sustained 5-HT2B activation is linked to heart-valve fibrosis, so repeated use carries that cardiac concern in addition to the serotonergic effects.
receptor fingerprint
transporter (SERT)Releasing agent / reuptake inhibitor
5-HT2B receptorPresumed agonist
()Releasing agent / reuptake inhibitor
Safetyrisks and cautions, not medical advice
5-MAPB carries the standard entactogen risks; serotonin syndrome with MAOIs and other serotonergic drugs, overheating, and cardiovascular strain. Its long duration can encourage unsafe redosing, and its benzofuran 5-HT2B agonism raises a specific concern about heart-valve damage with repeated exposure. Human safety data is thin. Not medical advice.
Subjective profileweighing the evidence above
Not a friendlier MDMA. It is a benzofuran, and the class carries a specific 5-HT2B concern about heart-valve damage with repeated use, stacked on top of the usual overheating, cardiovascular strain and serotonin toxicity risk. Human safety data is thin, and the long duration invites exactly the redosing that makes all of that worse.
Resources
No suppliers are provided for compounds like this. This entry is here for reference.
Research
- 2015first citedPharmacological profile of novel psychoactive benzofurans.
- 2023most recentLocomotor and discriminative stimulus effects of three benzofuran compounds in comparison to ab…
- 1.Pharmacological profile of novel psychoactive benzofurans.
- 2.Pharmacology of MDMA- and Amphetamine-Like New Psychoactive Substances.
- 3.The psychoactive aminoalkylbenzofuran derivatives, 5-APB and 6-APB, mimic the effects of 3,4-methylenedioxyamphetamine (MDA) on monoamine transmission in male rats.
- 4.Locomotor and discriminative stimulus effects of three benzofuran compounds in comparison to abused psychostimulants.
- 5.Benzofuran analogues of amphetamine and methamphetamine: studies on the metabolism and toxicological analysis of 5-APB and 5-MAPB in urine and plasma using GC-MS and LC-(HR)-MS(n) techniques.
- 6.New Psychoactive Substances: Chemistry, Pharmacology, Metabolism, and Detectability of Amphetamine Derivatives With Modified Ring Systems.
6 listed here; entry last updated July 2026
Reviews
My notesprivate to this device
FAQ
How does 5-MAPB relate to 5-APB?
It is the N-methyl version, similar to how MDMA relates to MDA, and is often reported as a bit smoother and more MDMA-like.
Does it still carry the heart-valve risk?
As a benzofuran it is presumed to keep 5-HT2B agonism, which is linked to valve damage with repeated use, so the concern remains.
Can it be mixed with serotonergic medications?
No. Combining it with MAOIs, SSRIs, or other serotonergic drugs risks serotonin syndrome.
Adverse effects
- Overheating (hyperthermia)
- Cardiovascular strain
Notes and cautions
- Long duration tempting redosing
- 5-HT2B-linked heart-valve concern