spec sheet10 rows
MDEA (MDE, N-ethyl-3,4-methylenedioxyamphetamine, "Eve") is the N-ethyl homologue of MDMA and a ring-substituted amphetamine that produces closely related entactogenic effects of warmth, empathy, and emotional openness, generally described as more sedating and less stimulating than MDMA. It triggers release of serotonin together with dopamine and norepinephrine and, unlike MDMA, shows relatively weak alpha2A-adrenoceptor activity, which prolongs its hypothermic response in animals. Its disposition is markedly enantioselective; the (R)-enantiomer reaches higher plasma concentrations and has a longer half-life, whereas the (S)-configured metabolites predominate, and MDEA is partly demethylated to the active metabolite MDA. It carries the characteristic risks of the MDMA class, including hyperthermia, serotonergic toxicity, and a contraindication against combination with monoamine oxidase inhibitors.
- Empathy and emotional openness
- Mood elevation
- Sense of closeness with others
- Mild stimulation
- N-ethyl MDMA analog with enantioselective pharmacokinetics
- Overheating (hyperthermia)
- Jaw clenching and teeth grinding
- Rapid heartbeat and raised blood pressure
- Post-use low mood ('comedown')
Mechanism
MDEA acts as a monoamine releasing agent: it enters neurons via the , , and transporters and reverses them, dumping stored serotonin (and to a lesser degree dopamine and norepinephrine) into the . The heavy serotonin release drives the empathogenic, emotionally open effects, while dopamine and norepinephrine add mild stimulation and cardiovascular load; the large serotonin surge is also what underlies its neurotoxic and serotonin-syndrome potential.
receptor fingerprint
transporter (SERT)Releasing agent (reverses transporter)
transporter (NET)Releasing agent
()Releasing agent
Safetyrisks and cautions, not medical advice
Because it floods serotonin, MDEA can cause life-threatening serotonin syndrome when combined with MAOIs or other strong serotonergic drugs, which is an absolute don't-mix. In warm, active settings it can cause dangerous overheating (hyperthermia) and, if people drink too much water without electrolytes, dangerous drops in blood sodium. It strains the heart, and repeated high-dose use raises concern for serotonergic neurotoxicity. Not medical advice.
Subjective profileweighing the evidence above
A softer, more sedating MDMA analog that trades push for calm, and it carries the same family risks: overheating in warm settings, cardiovascular strain and a real comedown. Never combine it with MAOIs or other strongly serotonergic drugs.
Resources
No suppliers are provided for compounds like this. This entry is here for reference.
Research
- 1996first citedFatal poisoning by MDMA (ecstasy) and MDEA: a case report.
- 2014most recentElucidating the neurotoxic effects of MDMA and its analogs.
- 1.Elucidating the neurotoxic effects of MDMA and its analogs.
- 2.Fatal poisoning by MDMA (ecstasy) and MDEA: a case report.
- 3.The Neuropsychopharmacology and Toxicology of 3,4-methylenedioxy-N-ethyl-amphetamine (MDEA).
- 4.Effects of MDMA, MDA and MDEA on blood pressure, heart rate, locomotor activity and body temperature in the rat involve alpha-adrenoceptors.
- 5.Enantioselective quantitation of the ecstasy compound (R)- and (S)-N-ethyl-3,4-methylenedioxyamphetamine and its major metabolites in human plasma and urine.
- 6.Quantitation of N-ethyl-3,4-methylenedioxyamphetamine and its major metabolites in human plasma by high-performance liquid chromatography and fluorescence detection.
6 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How is MDEA different from MDMA?
It is the N-ethyl version and tends to be reported as more sedating and less stimulating and euphoric, but its risk profile is broadly similar.
Can it be mixed with antidepressants or MAOIs?
No. Combining it with MAOIs or other serotonergic drugs risks serotonin syndrome, which can be fatal.
Why does overheating matter so much?
It raises body temperature and, in hot, active environments, hyperthermia is one of the most serious acute dangers of this drug class.
Adverse effects
- Overheating (hyperthermia)
- Jaw clenching and teeth grinding
- Rapid heartbeat and raised blood pressure
- Post-use low mood ('comedown')