data + articles · 9 listed
newest 2020spec sheet10 rows
6-APB (6-(2-aminopropyl)benzofuran), sold as "Benzo Fury," is a benzofuran entactogen and positional isomer of 5-APB. In vitro and in vivo studies show it acts as a potent substrate-type releaser at the dopamine, norepinephrine and serotonin transporters, with a profile closely mimicking that of MDA and MDMA but greater potency, producing sustained stimulant and empathogenic effects. It is also a partial 5-HT2A agonist and, of particular concern, a 5-HT2B receptor agonist, an activity associated with cardiac valvulopathy on repeated exposure. Its long duration encourages unsafe redosing, and case reports link its use to acute psychosis, sympathomimetic toxicity and fatalities in polydrug settings.
- Empathy and warmth
- Stimulation and energy
- Mild psychedelic quality
- Mood elevation
- Potent triple monoamine releaser with MDMA-like entactogenic profile
- Very long duration tempting redosing
- Overheating (hyperthermia)
- Cardiovascular strain
- 5-HT2B-linked heart-valve concern
Mechanism
6-APB acts as a releasing agent and at the , , and transporters, raising all three monoamines to produce its entactogenic and stimulant effects, with some direct serotonin-receptor agonism adding a psychedelic tinge. It is a potent 5-HT2B receptor ; because sustained 5-HT2B activation drives fibrotic heart-valve changes, repeated use raises a specific cardiac concern beyond the usual entactogen risks.
receptor fingerprint
transporter (SERT)Releasing agent / reuptake inhibitor
5-HT2B receptorAgonist
()Releasing agent / reuptake inhibitor
Safetyrisks and cautions, not medical advice
6-APB shares MDMA-style acute dangers; serotonin syndrome with MAOIs or other serotonergic drugs, overheating, and heavy cardiovascular strain. Its long duration frequently leads people to redose too soon and overshoot. Its potent 5-HT2B agonism raises real concern about heart-valve damage with repeated use, making regular use particularly ill-advised. Not medical advice.
Subjective profileweighing the evidence above
The 5-HT2B agonism is the dealbreaker, since sustained activation at that receptor is the mechanism behind fibrotic heart-valve damage, so repeated use is a bad trade whatever the warmth is worth. The marathon duration also invites exactly the redosing that drives overheating and cardiovascular strain.
Resources
No suppliers are provided for compounds like this. This entry is here for reference.
Research
- 2013first citedRecreational use of 1-(2-naphthyl)-2-(1-pyrrolidinyl)-1-pentanone hydrochloride (NRG-1), 6-(2-a…
- 2020most recentThe psychoactive aminoalkylbenzofuran derivatives, 5-APB and 6-APB, mimic the effects of 3,4-me…
- 1.Pharmacological profile of novel psychoactive benzofurans.
- 2.The psychoactive aminoalkylbenzofuran derivatives, 5-APB and 6-APB, mimic the effects of 3,4-methylenedioxyamphetamine (MDA) on monoamine transmission in male rats.
- 3.Emerging club drugs: 5-(2-aminopropyl)benzofuran (5-APB) is more toxic than its isomer 6-(2-aminopropyl)benzofuran (6-APB) in hepatocyte cellular models.
- 4.Pharmacokinetics, pharmacodynamics and toxicology of new psychoactive substances (NPS): 2C-B, 4-fluoroamphetamine and benzofurans.
- 5.New Psychoactive Substances: Chemistry, Pharmacology, Metabolism, and Detectability of Amphetamine Derivatives With Modified Ring Systems.
- 6.Monitoring new psychoactive substances (NPS) in The Netherlands: data from the drug market and the Poisons Information Centre.
- 7.Recreational use of 1-(2-naphthyl)-2-(1-pyrrolidinyl)-1-pentanone hydrochloride (NRG-1), 6-(2-aminopropyl) benzofuran (benzofury/6-APB) and NRG-2 with review of available evidence-based literature.
- 8.Four fatalities involving 5-IT.
- 9.Acute psychosis associated with recreational use of benzofuran 6-(2-aminopropyl)benzofuran (6-APB) and cannabis.
9 listed here; entry last updated July 2026
Reviews
My notesprivate to this device
FAQ
What is 'Benzo Fury'?
It was a common branded name for 6-APB sold as a legal high; despite the name it is not a benzodiazepine, it is a benzofuran entactogen.
Why worry about the heart with 6-APB?
It strongly activates the 5-HT2B receptor, and repeated activation is linked to fibrotic heart-valve damage.
Is the long duration a problem?
Yes; because it lasts so long, people often redose thinking it isn't working and end up far deeper and more strained than intended.
Adverse effects
- Very long duration tempting redosing
- Overheating (hyperthermia)
- Cardiovascular strain
- 5-HT2B-linked heart-valve concern