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Desoxypipradrol (2-DPMP) is a piperidine-based stimulant closely related to pipradrol and methylphenidate. It works by blocking the reuptake of dopamine and norepinephrine (so those signals stick around longer), which produces a strong, wakeful stimulation. What sets it apart is how long it lasts; effects can drag on for a day or more, which is where a lot of its trouble comes from.
- Strong, long-lasting wakefulness
- Increased focus and drive
- Reduced appetite
- Very long-lasting insomnia
- Cardiovascular strain
- Agitation and paranoia
- Stimulant psychosis risk
Mechanism
It acts as a and (it blocks the transporter proteins that normally recycle these neurotransmitters back into the cell). Unlike amphetamines it does not strongly force release; it mostly just prevents clearance. Its very long duration is thought to come from slow metabolism and a long , so the stimulation stacks up over time.
receptor fingerprint
()Reuptake inhibitor
transporter (NET)Reuptake inhibitor
Safetyrisks and cautions, not medical advice
Because it lasts so long, redosing or even a single dose can cause many hours of insomnia, racing heart, high blood pressure, agitation, and in reported cases paranoia and stimulant psychosis that outlast what people expect. It was linked to a wave of hospital admissions when sold as a research chemical or as "Ivory Wave". Stacking it with other stimulants, MAOIs, or serotonergic drugs raises cardiovascular and psychiatric risk sharply. Not medical advice.
Subjective profileweighing the evidence above
Not worth it under any framing. A single dose can outlast the day and leave insomnia, agitation and paranoia behind it, and it drove a wave of hospital admissions when it was sold openly. Whatever the wakefulness is worth, there is no dose that gives you the off switch back.
Resources
This entry is here for reference.
Research
- 1.The Role of Dopamine in the Stimulant Characteristics of Novel Psychoactive Substances (NPS)-Neurobiological and Computational Assessment Using the Case of Desoxypipradrol (2-DPMP)
- 2.[Desoxypipradrol - a new (already well known) designer drug]
2 listed here; entry last updated July 2026
Reviews
My notesprivate to this device
FAQ
Why is desoxypipradrol considered risky?
Its extreme duration means the stimulation and side effects pile up for a very long time, so a normal-seeming dose can leave someone wired and anxious for over a day.
How is it different from methylphenidate?
They share a similar reuptake-blocking mechanism, but desoxypipradrol lacks the ester group and lasts dramatically longer, making it far harder to control.
Is it the same as "Ivory Wave"?
Some products sold under that name contained desoxypipradrol, which is what triggered a cluster of hospitalizations.
Adverse effects
- Very long-lasting insomnia
- Cardiovascular strain
- Agitation and paranoia
- Stimulant psychosis risk