spec sheet10 rows
3,4-CTMP is a methylphenidate analog carrying two chlorine atoms on the phenyl ring, which makes it far more potent than methylphenidate itself. It blocks the reuptake of dopamine and norepinephrine, producing a strong, long-lasting stimulation. Its potency and long duration make compulsive redosing and cardiovascular strain a serious concern.
- Strong, long-lasting stimulation
- Intense focus
- Wakefulness
- Severe insomnia
- Anxiety and paranoia
Mechanism
3,4-CTMP is a - , binding the dopamine and norepinephrine transporters to block reuptake and raise levels of both. The two ring chlorines dramatically increase binding affinity at the compared with methylphenidate, which is why it is active at much lower amounts and lasts a long time. Unlike amphetamines it works mainly by blocking reuptake rather than triggering release.
receptor fingerprint
()Reuptake inhibitor
transporter (NET)Reuptake inhibitor
Safetyrisks and cautions, not medical advice
Its high potency and long duration make it easy to overshoot and hard to reverse, and the strong dopamine action drives compulsive redosing that can stretch into multi-day, sleep-deprived binges. Expect significant cardiovascular strain (raised heart rate and blood pressure, vasoconstriction) and a real risk of anxiety, paranoia, and dependence. Combining it with other stimulants or MAOIs is especially dangerous. Not medical advice.
Subjective profileweighing the evidence above
Not worth it. The extra potency over methylphenidate buys nothing useful, and the long duration is what does the damage: compulsive redosing, multi-day sleepless runs and real cardiovascular strain, on about two citations' worth of human knowledge.
Resources
This entry is here for reference.
Research
- 1.In Vitro Neurochemical Assessment of Methylphenidate and Its "Legal High" Analogs 3,4-CTMP and Ethylphenidate in Rat Nucleus Accumbens and Bed Nucleus of the Stria Terminalis.
- 2.Use of new psychoactive substances to mimic prescription drugs: The trend in France
2 listed here; entry last updated August 2026
Reviews
My notesprivate to this device
FAQ
How potent is 3,4-CTMP?
Much more potent than methylphenidate because the two ring chlorines greatly increase its grip on the dopamine transporter.
Why is it high risk?
The combination of high potency, long duration, and strong dopamine action makes overshooting and compulsive binging easy.
Is it addictive?
Yes. Potent dopamine reuptake inhibitors are strongly reinforcing and can drive dependence quickly.
Adverse effects
- Severe insomnia
- Anxiety and paranoia
Notes and cautions
- Marked cardiovascular strain
- Strong compulsive redosing