data + articles · 2 listed
newest 2018spec sheet10 rows
2-Aminoindane (2-AI) is a rigid, ring-locked analog of amphetamine in which the side chain is fused into an indane ring. It acts as a norepinephrine and dopamine releaser and reuptake inhibitor, giving a stimulant effect that leans strongly toward norepinephrine. It came out of research into constrained amphetamine structures and appears as a research chemical.
- Clean, physical stimulation
- Increased alertness
- Appetite suppression
- Strong rise in blood pressure
- Anxiety and insomnia
Mechanism
Locking the amphetamine side chain into a ring gives 2-AI a distinct selectivity; it releases and blocks reuptake of more strongly than or (it acts on the transporter proteins for these neurotransmitters). This norepinephrine-heavy profile makes it feel stimulating and physically activating but relatively low in euphoria. It served as a template for developing other rigid monoamine releasers.
receptor fingerprint
transporter (NET)Releasing agent / reuptake inhibitor
()Releasing agent / reuptake inhibitor
Safetyrisks and cautions, not medical advice
Its strong noradrenergic action means it can push blood pressure and heart rate up sharply, with anxiety, insomnia, and cardiovascular strain as the main risks. There is little human safety data, so its margins are poorly defined. Combining it with MAOIs, other stimulants, or serotonergic drugs raises cardiovascular and serotonergic risk. Not medical advice.
Subjective profileweighing the evidence above
Not worth it. A research-chemical stimulant with almost no human safety data, and the noradrenergic bias that makes it feel clean is exactly what pushes blood pressure and heart rate up hard. Nothing here that a studied stimulant does not do more predictably.
Resources
This entry is here for reference.
Research
- 1.Pharmacological profile of mephedrone analogs and related new psychoactive substances.
- 2.Pharmacological profiles of aminoindanes, piperazines, and pipradrol derivatives.
2 listed here; entry last updated July 2026
Reviews
My notesprivate to this device
FAQ
What makes 2-aminoindane unusual?
Its amphetamine-like side chain is fused into a rigid ring, which biases it toward releasing norepinephrine over dopamine.
Is it very euphoric?
Not especially; its noradrenergic lean makes it feel more physically stimulating and "wired" than rewarding.
Is there much safety data?
Very little. It comes mainly from pharmacology research, so its safe margins in humans are not well understood.
Adverse effects
- Strong rise in blood pressure
- Anxiety and insomnia
Notes and cautions
- Cardiovascular strain
- Low euphoria relative to load