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for educational and safety purposes
Letrozole and Exemestane both come up in the same conversations; they overlap on estrogen synthesis and aromatase enzyme. Letrozole: Letrozole is a nonsteroidal aromatase inhibitor used chiefly to treat hormone receptor-positive breast cancer in postmenopausal women, working by suppressing the enzyme that manufactures estrogen and thereby slowing tumors that depend on it. Exemestane: Exemestane is a steroidal aromatase inhibitor used chiefly to treat hormone-receptor-positive breast cancer in postmenopausal women.
Letrozole is a nonsteroidal aromatase inhibitor used chiefly to treat hormone receptor-positive breast cancer in postmenopausal women, working by suppressing the enzyme that manufactures estrogen and thereby slowing tumors that depend on it. In a notable paradox, the same estrogen suppression makes it an effective ovulation inducer, and because of its short half-life and monofollicular response it has become first-line for ovulation induction in polycystic ovary syndrome, where trials showed higher live-birth rates than clomiphene. It is also used off-label for endometriosis and is sold under the brand name Femara.
Exemestane is a steroidal aromatase inhibitor used chiefly to treat hormone-receptor-positive breast cancer in postmenopausal women. Sold under the brand name Aromasin, it lowers the body's estrogen supply by permanently inactivating aromatase, the enzyme that builds estrogen, and is taken as a once-daily oral tablet. It is also used off-label, mainly by men, to keep estrogen levels in check.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
inhibits
inhibits
blocks
blocks
modulates
activates
blocks
blocks
modulates
activates
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.