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for educational and safety purposes
Letrozole and Arimidex both come up in the same conversations. Letrozole: Letrozole is a nonsteroidal aromatase inhibitor used chiefly to treat hormone receptor-positive breast cancer in postmenopausal women, working by suppressing the enzyme that manufactures estrogen and thereby slowing tumors that depend on it. Arimidex: Arimidex is a brand name for anastrozole, a nonsteroidal aromatase inhibitor used mainly to treat hormone-receptor-positive breast cancer in postmenopausal women.
Letrozole is a nonsteroidal aromatase inhibitor used chiefly to treat hormone receptor-positive breast cancer in postmenopausal women, working by suppressing the enzyme that manufactures estrogen and thereby slowing tumors that depend on it. In a notable paradox, the same estrogen suppression makes it an effective ovulation inducer, and because of its short half-life and monofollicular response it has become first-line for ovulation induction in polycystic ovary syndrome, where trials showed higher live-birth rates than clomiphene. It is also used off-label for endometriosis and is sold under the brand name Femara.
Arimidex is a brand name for anastrozole, a nonsteroidal aromatase inhibitor used mainly to treat hormone-receptor-positive breast cancer in postmenopausal women. By blocking the aromatase enzyme it sharply lowers the body's estrogen, slowing cancers that depend on estrogen to grow, and it is used as adjuvant therapy after surgery, for advanced disease, and, as shown in the IBIS-II trial, for prevention in high-risk women. Its common side effects, including joint pain, hot flashes, and bone thinning, are direct consequences of that profound estrogen suppression, which is also the basis of concern about effects on cognition.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
inhibits
blocks
blocks
modulates
activates
non-steroidal inhibitor
reduces
blocks
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.