4-HO-MiPT vs 4-HO-MET

4-HO-MiPT (4-hydroxy-N-methyl-N-isopropyltryptamine; miprocin) is a synthetic tryptamine psychedelic and a close structural relative of psilocin, differing by an isopropyl group on the side chain. Its effects derive mainly from potent, efficacious agonism at the 5-HT2A serotonin receptor, with EC50 values in the low-nanomolar range and additional activity across the 5-HT2 family; in the mouse head-twitch model it is a robust psychedelic whose response can be blunted by serotonin transporter inhibition, illustrating how transporter engagement modulates the tryptamine experience. In rats, closely related 4-substituted tryptamines fully substitute for the discriminative stimulus of DOM, consistent with a classic hallucinogen profile. Users often describe it as comparatively gentle and clear-headed, though set and setting remain important.

effects

Serotonin

targets

5-HT2A receptor, 5-HT2C receptor, 5-HT1A receptor

suppliers

reference only

4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine; metocin) is a synthetic tryptamine and the methyl-ethyl homolog of psilocin. It behaves as a 5-HT2A serotonin receptor agonist, and in trained rats it fully substitutes for the discriminative stimulus of the psychedelic DOM at potencies at or below that reference agonist, supporting a classic hallucinogen profile and associated abuse liability. Users commonly describe a relatively gentle, colorful, and euphoric experience. Clinical toxicology characterization of a non-fatal intoxication established that 4-HO-MET can be identified from blood plasma using liquid chromatography high-resolution mass spectrometry, with a measured plasma concentration of about 193 ng/mL and detectable N-demethyl, oxo, hydroxy, and N-oxide metabolites, whereas gas chromatography-mass spectrometry failed to detect the parent compound.

effects

Serotonin

targets

5-HT2A receptor, 5-HT1A receptor, 5-HT2C receptor

suppliers

reference only