4-HO-DiPT vs 4-HO-MiPT

4-HO-DiPT (4-hydroxy-N,N-diisopropyltryptamine) is a synthetic tryptamine and the diisopropyl homolog of psilocin. It acts as an agonist at the 5-HT2A serotonin receptor, and preclinical target profiling indicates broader activity across serotonin receptor subtypes typical of the tryptamine class; in rats it fully substitutes for the discriminative stimulus of the psychedelic DOM. Its distinguishing feature is an unusually rapid onset and notably short duration of action, a property that motivated development of RE104, a glutarate ester prodrug of 4-HO-DiPT that has entered phase 1 human trials as a shorter-duration alternative to psilocybin for depressive disorders. Human pharmacokinetic work shows plasma 4-HO-DiPT appearing within about an hour and correlating with mystical-type and drug-effect measures, and its metabolism proceeds mainly through glucuronidation, sulfation, and N-dealkylation.

effects

Serotonin

targets

5-HT2A receptor, 5-HT1A receptor, 5-HT2C receptor

suppliers

reference only

4-HO-MiPT (4-hydroxy-N-methyl-N-isopropyltryptamine; miprocin) is a synthetic tryptamine psychedelic and a close structural relative of psilocin, differing by an isopropyl group on the side chain. Its effects derive mainly from potent, efficacious agonism at the 5-HT2A serotonin receptor, with EC50 values in the low-nanomolar range and additional activity across the 5-HT2 family; in the mouse head-twitch model it is a robust psychedelic whose response can be blunted by serotonin transporter inhibition, illustrating how transporter engagement modulates the tryptamine experience. In rats, closely related 4-substituted tryptamines fully substitute for the discriminative stimulus of DOM, consistent with a classic hallucinogen profile. Users often describe it as comparatively gentle and clear-headed, though set and setting remain important.

effects

Serotonin

targets

5-HT2A receptor, 5-HT2C receptor, 5-HT1A receptor

suppliers

reference only