4-HO-MiPT vs 4-AcO-MiPT

4-HO-MiPT (4-hydroxy-N-methyl-N-isopropyltryptamine; miprocin) is a synthetic tryptamine psychedelic and a close structural relative of psilocin, differing by an isopropyl group on the side chain. Its effects derive mainly from potent, efficacious agonism at the 5-HT2A serotonin receptor, with EC50 values in the low-nanomolar range and additional activity across the 5-HT2 family; in the mouse head-twitch model it is a robust psychedelic whose response can be blunted by serotonin transporter inhibition, illustrating how transporter engagement modulates the tryptamine experience. In rats, closely related 4-substituted tryptamines fully substitute for the discriminative stimulus of DOM, consistent with a classic hallucinogen profile. Users often describe it as comparatively gentle and clear-headed, though set and setting remain important.

effects

Serotonin

targets

5-HT2A receptor, 5-HT2C receptor, 5-HT1A receptor

suppliers

reference only

4-AcO-MiPT (4-acetoxy-N-methyl-N-isopropyltryptamine) is a synthetic tryptamine, the acetate ester of 4-HO-MiPT and a close analog of psilacetin. It is thought to act as a prodrug for the active 4-HO-MiPT, a full agonist at the 5-HT2A serotonin receptor that mediates its psilocybin-like psychedelic effects. In rodent drug-discrimination studies 4-AcO-MiPT fully substitutes for the classic hallucinogen DOM, supporting a shared serotonergic mechanism, and structure-activity work classes it among psilocybin-like tryptamines whose acetate esters appear to behave as prodrugs. Comparative pharmacology of the MiPT series indicates that concurrent serotonin transporter inhibition can blunt psychedelic-like effects, a property relevant across the broader tryptamine family. Human data specific to 4-AcO-MiPT remain limited.

effects

Serotonin

targets

5-HT2A receptor, 5-HT1A receptor, 5-HT2C receptor

suppliers

reference only