4-HO-MET vs 4-AcO-MET

4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine; metocin) is a synthetic tryptamine and the methyl-ethyl homolog of psilocin. It behaves as a 5-HT2A serotonin receptor agonist, and in trained rats it fully substitutes for the discriminative stimulus of the psychedelic DOM at potencies at or below that reference agonist, supporting a classic hallucinogen profile and associated abuse liability. Users commonly describe a relatively gentle, colorful, and euphoric experience. Clinical toxicology characterization of a non-fatal intoxication established that 4-HO-MET can be identified from blood plasma using liquid chromatography high-resolution mass spectrometry, with a measured plasma concentration of about 193 ng/mL and detectable N-demethyl, oxo, hydroxy, and N-oxide metabolites, whereas gas chromatography-mass spectrometry failed to detect the parent compound.

effects

Serotonin

targets

5-HT2A receptor, 5-HT1A receptor, 5-HT2C receptor

suppliers

reference only

4-AcO-MET (4-acetoxy-N-methyl-N-ethyltryptamine) is a synthetic tryptamine, the acetate ester of 4-HO-MET and an asymmetric N-alkyl variant of psilacetin. It is generally considered a prodrug that is hydrolyzed to the active 4-HO-MET, an agonist at the 5-HT2A serotonin receptor producing psilocybin-like effects; structure-activity data indicate that O-acetylation attenuates in vitro 5-HT2A potency while preserving agonist efficacy. Its 4-hydroxy metabolite fully substitutes for the hallucinogen DOM in rodent drug-discrimination testing, and in vitro toxicology has identified hERG channel inhibition and QT prolongation as potential cardiac concerns. The compound and its metabolite have been documented in forensic casework and characterized by crystallographic and analytical methods. Controlled human pharmacology is not well established.

effects

Serotonin

targets

5-HT2A receptor, 5-HT1A receptor, 5-HT2C receptor

suppliers

reference only