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Amoxicillin is a widely used antibiotic of the penicillin family, specifically an aminopenicillin, effective against many common bacterial infections. It works by disrupting the construction of the bacterial cell wall, killing susceptible bacteria [1]. Taken by mouth, it is a first-choice treatment for conditions such as middle-ear infections, streptococcal sore throat, and community-acquired pneumonia, and it is one of the most frequently prescribed medicines worldwide [2][3][4].
Azithromycin is a broad-spectrum antibiotic in the macrolide family, specifically the first of the azalide subclass, sold under brand names such as Zithromax and the Z-Pak. It treats a range of bacterial infections, including respiratory, skin, and sexually transmitted infections. Discovered by scientists at the Croatian company Pliva in the early 1980s, it is known for concentrating heavily in body tissues and having a long half-life, which allows short, simple courses of treatment.
Cefixime is an orally administered third-generation cephalosporin antibiotic used to treat a range of bacterial infections [1][2]. It works by disrupting construction of the bacterial cell wall and is notably resistant to breakdown by many bacterial beta-lactamase enzymes [2]. Common uses include urinary tract infections, middle-ear infections, pharyngitis, and certain respiratory and sexually transmitted infections [2][3]. First patented in 1979 and approved in the United States in 1989, cefixime is listed on the World Health Organization Model List of Essential Medicines [1].
Cefpodoxime is an orally active third-generation cephalosporin antibiotic used against a broad range of bacterial infections [1][2]. It is given as the prodrug cefpodoxime proxetil, an inactive ester that is converted to the active drug during absorption from the gut [2]. Like other cephalosporins it kills bacteria by blocking cell-wall construction, and it stays stable in the presence of many common beta-lactamase enzymes [2]. First patented in 1980 and approved for medical use in 1989, it is marketed under brand names such as Vantin and Orelox [1].
Cephalexin, also spelled cefalexin, is a first-generation cephalosporin antibiotic taken by mouth to treat a variety of common bacterial infections [1][2]. It works by blocking construction of the bacterial cell wall and is used chiefly against gram-positive organisms, in conditions such as skin infections, strep throat, ear infections, and urinary tract infections [1][2]. First marketed in 1969 under the brand name Keflex, it is inexpensive, widely available as a generic, and listed on the World Health Organization Model List of Essential Medicines [1]. It is generally well tolerated, with digestive upset among the more common side effects [1][2].
Clarithromycin is a macrolide antibiotic, a semisynthetic derivative of erythromycin developed to be more acid-stable and better absorbed. It is used to treat respiratory tract infections, skin and soft-tissue infections, Helicobacter pylori, and certain mycobacterial infections. It stops bacteria from making proteins, and it is notable both for interacting with many other medicines and for cautions about heart rhythm.