Prostate: nootropics and compounds | sci-wiki

Andarine

Andarine (S-4) is a non-steroidal selective androgen receptor modulator derived from arylpropionamide chemistry that binds the androgen receptor with high affinity yet acts in a tissue-selective manner. In castrated and ovariectomized rodents it restored skeletal muscle mass and strength, raised bone mineral density, and reduced body fat while stimulating the prostate and seminal vesicles far less than dihydrotestosterone; this partial-agonist behavior in androgenic organs versus full-agonist activity in muscle and bone defines the SARM concept. Its favorable pharmacokinetics, including high oral bioavailability and predominantly hepatic phase I and II metabolism, once positioned it as a clinical candidate for muscle wasting and osteoporosis. It was never approved for human use, however, and is prohibited in sport, so it is documented largely through preclinical pharmacology and anti-doping detection studies rather than clinical trials.

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SARM

LGD-2226

LGD-2226 is a first-generation selective androgen receptor modulator (SARM) developed to build muscle and bone with far less impact on the prostate than traditional androgens. In animal studies it increased muscle and bone mass and enhanced bone strength while sparing the prostate and preserving male sexual behavior, showcasing the tissue selectivity that defines the SARM class. Orally active and non-steroidal, LGD-2226 is a notable early example of the effort to capture the benefits of androgens while minimizing their drawbacks.

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Supplement

Pygeum

Pygeum is a fat-soluble extract of the bark of Prunus africana (the African cherry, sometimes called the African plum tree), and its whole reputation rests on one job: easing the urinary symptoms of benign prostatic hyperplasia (BPH, the non-cancerous prostate enlargement that makes older men get up at night and struggle to fully empty the bladder). The bark is standardized to a blend of fat-soluble actives; phytosterols like beta-sitosterol, pentacyclic triterpenes, and ferulic acid esters; which together are thought to calm prostate inflammation and soften the hormone and growth-factor signals that drive the gland to swell. It has been used in Europe as a prescription-grade BPH remedy since the 1960s, and it is one of the two herbs (saw palmetto is the other) that men reach for first when they want a plant option before or alongside medication.

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Antiandrogen

Bicalutamide

Bicalutamide is a nonsteroidal antiandrogen, a drug that blocks the action of male sex hormones by competitively antagonizing the androgen receptor. It is used mainly in the treatment of prostate cancer, either combined with medical or surgical castration in advanced disease or, at a higher dose, as a single agent in earlier disease [1]. First approved in the mid-1990s under the brand name Casodex, it is taken as a once-daily oral tablet and is now available as a generic on the World Health Organization's List of Essential Medicines. Unlike some related drugs, it reduces androgen signaling without lowering the body's production of testosterone [1].

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Cardiovascular

Silodosin

Silodosin is a selective alpha-1A adrenergic receptor antagonist, a type of alpha blocker, used to relieve the urinary symptoms of benign prostatic hyperplasia (BPH). By relaxing smooth muscle in the prostate, bladder neck, and urethra, it improves urine flow in men with an enlarged prostate. First approved in Japan in 2006 and sold under brand names such as Rapaflo and Urorec, it is noted for a high selectivity that limits blood-pressure effects but commonly causes abnormal ejaculation.

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