Pipofezine is a sedating tricyclic antidepressant developed in the Soviet Union and still used in Russia and neighbouring countries; it has never been approved in the European Union or the United States and there is very little independent trial evidence for it.
- Soviet era tricyclic antidepressant, still prescribed across Russia
- Lifts mood by raising serotonin and noradrenaline
- Heavy H1 blockade; genuinely sedating for evening dosing
- Claimed to skip amitriptyline's dry mouth and cardiac load
- A rare find outside its home region
Mechanism
As a pyrazinoindole tricyclic it inhibits and noradrenaline reuptake in the manner of the older antidepressants, with strong H1 blockade that accounts for the sedation. Russian sources report that it lacks the marked anticholinergic and cardiotoxic profile of amitriptyline; that comparison has not been independently replicated and should be treated as a claim rather than a finding.
Safetyrisks and cautions, not medical advice
a tricyclic antidepressant with the class hazards of overdose and serotonergic interaction, prescribed on the strength of an evidence base that has never been examined outside its home region
Subjective profileweighing the evidence above
The claim carrying this drug is that it does the work of amitriptyline without the anticholinergic load and the cardiac risk, and nobody outside the region that makes it has ever checked. It could be true, and a tricyclic that is gentler on the heart would be genuinely worth having. Until someone tests it, it carries the full class hazard in overdose, which matters more than usual in a drug given for depression, and the sedation is heavy enough that it sits better at the end of the day than the start.
Where to buy
Suppliers
Vendors carrying Pipofezine, with live product details and codes. Links are affiliate links that support the wiki at no cost to you.
RUPharma🌐
Pipofezine