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Almestrone A synthetic steroidal estrogen synthesized in 1967 that was never marketed as a drug. It instead became an important synthetic intermediate for other steroids, most notably the original Organon route to the drug tibolone.
- Served as the key synthetic intermediate in the original industrial route to tibolone
- Also used to synthesize other steroids, including dimethandrolone and dimethyltrienolone
Overview
Never sold as its own medicine; its real legacy is as a building block chemists used to make tibolone and other steroids.
Mechanism
As a 7alpha-methyl analog of the natural estrone, almestrone is presumed to act as an estrogen receptor similarly to estrone. It was studied primarily as a chemical synthesis intermediate rather than being directly tested for pharmacologic effect.
receptor fingerprint
receptorAgonist
Safetyrisks and cautions, not medical advice
Almestrone was never developed as a therapeutic agent, so no dedicated human safety data exists. It has been used only as a laboratory synthesis intermediate.
Subjective profileweighing the evidence above
Not a drug and never meant to be one; its whole significance is industrial, as the stepping stone to tibolone and a few other steroids. Interesting to chemists, irrelevant to anyone deciding what to take.
Resources
This entry is here for reference.
Reviews
My notesprivate to this device
FAQ
What is Almestrone used for?
It was never used as a medicine; its main role is as a chemical intermediate in the synthesis of other steroids, including the original route to tibolone.
How does Almestrone work?
Structurally it resembles the natural estrogen estrone, so it is presumed to act as a weak estrogen receptor agonist, though this was never the focus of its use.
Is Almestrone well-researched?
No. It exists mainly in steroid chemistry literature as a synthesis intermediate rather than in pharmacological studies.
Limitations of the evidence
- Never tested in humans as a drug in its own right
- No established safety or side-effect data exists