LDL cholesterol: nootropics and compounds | sci-wiki

Dihydroberberine

Dihydroberberine (DHB) is a reduced, or hydrogenated, form of berberine; basically the same molecule with two extra hydrogen atoms tacked on. Once it hits the gut it gets converted right back to berberine, so you end up with all the familiar berberine effects (blood sugar control, better lipids, AMPK activation) but from a much smaller dose. The whole reason DHB exists is absorption. Plain berberine is notoriously hard to get into the bloodstream, so DHB is the clever workaround. Think of it as the same engine with a better fuel line; nothing new downstream, just far more of it actually reaching your cells. People reach for it for the same goals as berberine: steadier blood sugar, improved insulin sensitivity, healthier cholesterol and triglycerides, and that "exercise in a pill" AMPK effect on the cell's energy machinery.

1 outlet

Statin

Atorvastatin

Atorvastatin is a lipid-lowering medication in the statin class, sold originally under the brand name Lipitor. It works by inhibiting HMG-CoA reductase, a liver enzyme central to cholesterol production, which lowers LDL (low-density lipoprotein) cholesterol and reduces the risk of heart attacks and strokes. Introduced in 1996 and once the best-selling drug in the world, it is now a widely used inexpensive generic and appears on the World Health Organization's List of Essential Medicines.

2 outlets

Cardiovascular

Bempedoic Acid

Bempedoic acid is an oral cholesterol-lowering drug and the first of a class that inhibits the enzyme ATP-citrate lyase, sold under brand names such as Nexletol and Nilemdo. It reduces LDL cholesterol by curbing cholesterol production in the liver, and because it is activated only in the liver and not in muscle, it tends to cause fewer muscle complaints than statins, which makes it useful for people who cannot tolerate statins. A large outcomes trial showed it lowers the risk of cardiovascular events, and it is also sold combined with ezetimibe.

1 outlet

Blend

Bempedoic Acid + Ezetimibe

Bempedoic acid plus ezetimibe is a fixed-dose combination tablet that pairs two non-statin cholesterol-lowering drugs, marketed as Nexlizet in the United States and Nustendi in Europe. Bempedoic acid curbs the liver's production of cholesterol while ezetimibe blocks cholesterol absorption in the gut, so together they lower LDL cholesterol more than either does alone. The combination is used for people who need additional LDL reduction, particularly those who cannot tolerate statins or have not reached their targets on them.

1 outlet

Cardiovascular

Evolocumab

Evolocumab is a biologic medication used to lower cholesterol, belonging to a class of drugs called PCSK9 inhibitors. It is a monoclonal antibody that blocks the protein PCSK9, allowing the liver to clear more low-density lipoprotein (LDL) cholesterol from the blood. Given by injection under the skin, it is used to treat high cholesterol, including the inherited form known as familial hypercholesterolemia, and to reduce the risk of heart attacks and strokes in people with cardiovascular disease. Developed by Amgen and approved in 2015, it is sold under the brand name Repatha.

1 outlet