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Mephenaqualone is a quinazolinone sedative-hypnotic, a close structural analog of methaqualone (the Quaalude drug). It is presumed to share methaqualone's mechanism, calming the brain by enhancing GABA, the main inhibitory neurotransmitter, to produce sedation and muscle relaxation. It is an obscure compound with little human data, and like all CNS depressants it is dangerous combined with other depressants.
- Sedation and calm
- Muscle relaxation
- Deep sedation and impaired coordination
- Likely dependence with regular use
Mechanism
Mephenaqualone is a quinazolinone analog of methaqualone and is presumed to act, like its parent, as a positive modulator of the -A receptor, enhancing GABA-driven chloride flow and dampening neural activity to produce sedation and muscle relaxation. Its precise potency and receptor affinities in humans are not well characterized, so the mechanism is described conservatively by analogy to methaqualone.
receptor fingerprint
-A receptorPositive allosteric modulator
Dosingtypical ranges, not medical advice
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Safetyrisks and cautions, not medical advice
As a sedative-hypnotic depressant, mephenaqualone is dangerous combined with alcohol, opioids or benzodiazepines, which stack respiratory depression and can be fatal. Because it is an obscure research compound, its true potency is uncertain, making doses easy to misjudge, and depressants of this type carry risks of over-sedation, dependence and difficult withdrawal. Not medical advice.
Subjective profileweighing the evidence above
Avoid it. An obscure quinazolinone with essentially no human data, uncertain potency that makes doses easy to misjudge, and every hazard of the depressant class: over-sedation, dependence, and fatal respiratory depression when combined with alcohol or opioids.
Resources
This entry is here for reference.
Research
1 listed here; entry last updated July 2026
Reviews
My notesprivate to this device
FAQ
How is it related to methaqualone?
It is a close quinazolinone analog of methaqualone (Quaalude) and is presumed to share its GABA-A sedative mechanism.
How much is known about it?
Very little; it is an obscure compound with scant human data, so its potency and effects are described cautiously by analogy to methaqualone.
Why the caution about mixing?
Like all CNS depressants it can suppress breathing, so combining it with alcohol or opioids is dangerous.
Limitations of the evidence
- Uncertain potency (obscure compound)
Adverse effects
- Deep sedation and impaired coordination
- Likely dependence with regular use
Notes and cautions
- Dangerous with alcohol or opioids