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for educational and safety purposes
Tesofensine and Phentermine both come up in the same conversations; they overlap on Dopamine and Norepinephrine. Tesofensine: Tesofensine is a triple monoamine reuptake inhibitor, originally investigated for Parkinson's and Alzheimer's disease, that produced some of the largest weight losses reported for an appetite-suppressing drug. Phentermine: Phentermine is a prescription appetite-suppressant stimulant and the most widely prescribed weight-loss drug; it is an amphetamine relative that curbs hunger by triggering the release of norepinephrine (and, more weakly, dopamine) in the brain, which the hypothalamus reads as fullness.
Tesofensine is a triple monoamine reuptake inhibitor, originally investigated for Parkinson's and Alzheimer's disease, that produced some of the largest weight losses reported for an appetite-suppressing drug. By simultaneously blocking the reuptake of dopamine, noradrenaline, and serotonin it curbs hunger and increases satiety, and it additionally silences appetite-driving GABAergic neurons in the hypothalamus. In a phase 2 obesity trial it produced weight loss roughly twice that of the obesity medications approved at the time, though that trial has carried an expression of concern over its adverse-effect reporting since 2013; it remains investigational, with cardiovascular effects among the safety considerations.
Phentermine is a prescription appetite-suppressant stimulant and the most widely prescribed weight-loss drug; it is an amphetamine relative that curbs hunger by triggering the release of norepinephrine (and, more weakly, dopamine) in the brain, which the hypothalamus reads as fullness. It is used short-term for obesity, often paired with topiramate as the combination drug Qsymia.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
triple reuptake inhibitor
raises
silences
releaser
releaser
agonist
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.
easiest to source: Tesofensine is currently listed by more trusted vendors (2), so it's the simpler one to get hold of. for effects and safety, read each full entry; this is educational, not medical advice.