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for educational and safety purposes
Phentermine and Chlorphentermine both come up in the same conversations; they overlap on Norepinephrine and Appetite. Phentermine: Phentermine is a prescription appetite-suppressant stimulant and the most widely prescribed weight-loss drug; it is an amphetamine relative that curbs hunger by triggering the release of norepinephrine (and, more weakly, dopamine) in the brain, which the hypothalamus reads as fullness. Chlorphentermine: Chlorphentermine is a discontinued appetite suppressant, the para-chloro version of phentermine; adding a chlorine to the ring flips its character from a norepinephrine releaser toward a serotonin releaser, making it a less stimulating, more serotonergic anorectic.
Phentermine is a prescription appetite-suppressant stimulant and the most widely prescribed weight-loss drug; it is an amphetamine relative that curbs hunger by triggering the release of norepinephrine (and, more weakly, dopamine) in the brain, which the hypothalamus reads as fullness. It is used short-term for obesity, often paired with topiramate as the combination drug Qsymia.
Chlorphentermine is a discontinued appetite suppressant, the para-chloro version of phentermine; adding a chlorine to the ring flips its character from a norepinephrine releaser toward a serotonin releaser, making it a less stimulating, more serotonergic anorectic. It was withdrawn because serotonergic appetite suppressants of its era turned out to damage heart valves and the lungs.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
releaser
releaser
releaser
agonist
releaser
indirect agonism (via serotonin release)
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.