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for educational and safety purposes
SR-9009 and SR-9011 both come up in the same conversations; they overlap on Mitochondria. SR-9009: SR-9009, also known as Stenabolic, is a synthetic agonist of the nuclear receptors REV-ERB-alpha and REV-ERB-beta, core repressive components of the circadian clock that link the body's timekeeping to metabolism. SR-9011: SR-9011 is a synthetic agonist of the REV-ERB nuclear receptors and a close structural analogue of SR-9009.
SR-9009, also known as Stenabolic, is a synthetic agonist of the nuclear receptors REV-ERB-alpha and REV-ERB-beta, core repressive components of the circadian clock that link the body's timekeeping to metabolism. By activating REV-ERB, it reprograms clock and metabolic gene expression across the hypothalamus, liver, skeletal muscle, and adipose tissue; in mice it increases energy expenditure, reduces fat mass, improves dyslipidemia and hyperglycemia, alters sleep architecture, and raises mitochondrial content and endurance capacity through the Rev-erb-alpha to LKB1-AMPK-SIRT1-PGC-1alpha pathway. Pharmacological REV-ERB activation has also proven selectively lethal to cancer cells and oncogene-induced senescent cells by suppressing autophagy and de novo lipogenesis. Studies using conditional REV-ERB knockouts have shown that some of SR-9009's actions persist without the receptors, indicating REV-ERB-independent off-target effects and reinforcing its status as a research tool rather than an approved therapeutic.
SR-9011 is a synthetic agonist of the REV-ERB nuclear receptors and a close structural analogue of SR-9009. Acting on these circadian clock receptors, it reprograms fuel metabolism across the day, and in rodents it raises energy expenditure and fat oxidation while reducing body weight. It is widely used as a research tool for dissecting how the body clock connects to metabolism, immunity, sleep, and cell proliferation.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
Upregulates mitochondrial content in muscle
Agonist that represses clock and metabolic genes
Suppresses IL-6, IL-1b, and MCP-1 output
agonist
agonist
suppresses
modulates
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.
easiest to source: SR-9009 is currently listed by more trusted vendors (2), so it's the simpler one to get hold of. for effects and safety, read each full entry; this is educational, not medical advice.