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for educational and safety purposes
Harmine and Harmaline both come up in the same conversations; they overlap on Serotonin. Harmine: Harmine is a beta-carboline alkaloid found in the vine Banisteriopsis caapi and in Peganum harmala (Syrian rue), and it is one of the harmala alkaloids that give ayahuasca its oral activity. Harmaline: Harmaline is a beta-carboline alkaloid closely related to harmine, differing by being partly reduced (dihydro) on the pyridine ring, and it occurs alongside harmine in Banisteriopsis caapi and Peganum harmala (Syrian rue).
Harmine is a beta-carboline alkaloid found in the vine Banisteriopsis caapi and in Peganum harmala (Syrian rue), and it is one of the harmala alkaloids that give ayahuasca its oral activity. Pharmacologically it is a reversible, competitive inhibitor of monoamine oxidase A (MAO-A), the property that protects DMT from breakdown in the ayahuasca brew and raises brain levels of serotonin and other monoamines. Beyond its role as an MAO inhibitor, harmine has attracted intense biomedical interest as a potent inhibitor of the kinase DYRK1A, an action through which it drives replication of human pancreatic beta cells and has become a leading template for diabetes regeneration research. It has additionally shown antidepressant-like, anti-inflammatory, and neuroprotective effects in preclinical models.
Harmaline is a beta-carboline alkaloid closely related to harmine, differing by being partly reduced (dihydro) on the pyridine ring, and it occurs alongside harmine in Banisteriopsis caapi and Peganum harmala (Syrian rue). Like harmine it is a reversible, competitive inhibitor of monoamine oxidase A (MAO-A), and it is one of the harmala alkaloids that confer oral activity on DMT in ayahuasca by protecting it from enzymatic breakdown. Harmaline is best known pharmacologically as a classic tremorgenic agent: it drives rhythmic firing in the inferior olive of the brainstem to produce a well-characterized whole-body tremor that neuroscientists use as an experimental model of essential tremor. Its effects on serotonergic tone and monoamine metabolism underlie both this motor action and its contribution to the ayahuasca experience.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
Reversible competitive inhibitor
Reversible competitive inhibitor
Weak agonist
Weak agonist
Inhibitor
Inhibitor
Synchronizing agonist effect
Inhibitor
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.