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for educational and safety purposes
Harmine and Banisteriopsis caapi both come up in the same conversations; they overlap on Serotonin. Harmine: Harmine is a beta-carboline alkaloid found in the vine Banisteriopsis caapi and in Peganum harmala (Syrian rue), and it is one of the harmala alkaloids that give ayahuasca its oral activity. Banisteriopsis caapi: Banisteriopsis caapi is a South American vine that is the backbone of the traditional ayahuasca brew.
Harmine is a beta-carboline alkaloid found in the vine Banisteriopsis caapi and in Peganum harmala (Syrian rue), and it is one of the harmala alkaloids that give ayahuasca its oral activity. Pharmacologically it is a reversible, competitive inhibitor of monoamine oxidase A (MAO-A), the property that protects DMT from breakdown in the ayahuasca brew and raises brain levels of serotonin and other monoamines. Beyond its role as an MAO inhibitor, harmine has attracted intense biomedical interest as a potent inhibitor of the kinase DYRK1A, an action through which it drives replication of human pancreatic beta cells and has become a leading template for diabetes regeneration research. It has additionally shown antidepressant-like, anti-inflammatory, and neuroprotective effects in preclinical models.
Banisteriopsis caapi is a South American vine that is the backbone of the traditional ayahuasca brew. Its psychoactivity comes from harmala alkaloids, which are reversible monoamine oxidase inhibitors (MAOIs); in ayahuasca they let orally-taken DMT reach the brain by blocking the enzyme that would otherwise destroy it. On its own the vine is mildly psychoactive and purgative, but its MAOI activity is the pharmacologically important and risky part.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
Reversible competitive inhibitor
Reversible inhibitor
Inhibitor
Inhibitor
Weak agonist
Reuptake inhibitor
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.