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for educational and safety purposes
Harmaline and Banisteriopsis caapi both come up in the same conversations; they overlap on Serotonin. Harmaline: Harmaline is a beta-carboline alkaloid closely related to harmine, differing by being partly reduced (dihydro) on the pyridine ring, and it occurs alongside harmine in Banisteriopsis caapi and Peganum harmala (Syrian rue). Banisteriopsis caapi: Banisteriopsis caapi is a South American vine that is the backbone of the traditional ayahuasca brew.
Harmaline is a beta-carboline alkaloid closely related to harmine, differing by being partly reduced (dihydro) on the pyridine ring, and it occurs alongside harmine in Banisteriopsis caapi and Peganum harmala (Syrian rue). Like harmine it is a reversible, competitive inhibitor of monoamine oxidase A (MAO-A), and it is one of the harmala alkaloids that confer oral activity on DMT in ayahuasca by protecting it from enzymatic breakdown. Harmaline is best known pharmacologically as a classic tremorgenic agent: it drives rhythmic firing in the inferior olive of the brainstem to produce a well-characterized whole-body tremor that neuroscientists use as an experimental model of essential tremor. Its effects on serotonergic tone and monoamine metabolism underlie both this motor action and its contribution to the ayahuasca experience.
Banisteriopsis caapi is a South American vine that is the backbone of the traditional ayahuasca brew. Its psychoactivity comes from harmala alkaloids, which are reversible monoamine oxidase inhibitors (MAOIs); in ayahuasca they let orally-taken DMT reach the brain by blocking the enzyme that would otherwise destroy it. On its own the vine is mildly psychoactive and purgative, but its MAOI activity is the pharmacologically important and risky part.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
Reversible competitive inhibitor
Reversible inhibitor
Synchronizing agonist effect
Inhibitor
Weak agonist
Reuptake inhibitor
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.