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for educational and safety purposes
Evolocumab and Ezetimibe both come up in the same conversations. Evolocumab: Evolocumab is a biologic medication used to lower cholesterol, belonging to a class of drugs called PCSK9 inhibitors. Ezetimibe: Ezetimibe is a cholesterol absorption inhibitor used to lower blood cholesterol, most often alongside a statin.
Evolocumab is a biologic medication used to lower cholesterol, belonging to a class of drugs called PCSK9 inhibitors. It is a monoclonal antibody that blocks the protein PCSK9, allowing the liver to clear more low-density lipoprotein (LDL) cholesterol from the blood. Given by injection under the skin, it is used to treat high cholesterol, including the inherited form known as familial hypercholesterolemia, and to reduce the risk of heart attacks and strokes in people with cardiovascular disease. Developed by Amgen and approved in 2015, it is sold under the brand name Repatha.
Ezetimibe is a cholesterol absorption inhibitor used to lower blood cholesterol, most often alongside a statin. Sold under the brand name Zetia among others, it acts in the small intestine to block the transport protein that ferries dietary and biliary cholesterol into the body. It is taken as an oral tablet for high cholesterol and related lipid disorders.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
activates
blocks
inhibits
blocks
modulates
blocks
inhibits
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.