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for educational and safety purposes
DOB and DOC both come up in the same conversations; they overlap on Serotonin. DOB: DOB (4-bromo-2,5-dimethoxyamphetamine) is a potent, very long-acting psychedelic amphetamine of the DOx family, bearing a bromine at the 4 position. DOC: DOC (4-chloro-2,5-dimethoxyamphetamine) is a potent, very long-acting psychedelic amphetamine of the DOx family, bearing a chlorine at the 4 position.
DOB (4-bromo-2,5-dimethoxyamphetamine) is a potent, very long-acting psychedelic amphetamine of the DOx family, bearing a bromine at the 4 position. It acts as an agonist at the 5-HT2A serotonin receptor, and the 2,5-dimethoxy substitution pattern is a key determinant of high-affinity binding and agonist activity at this site; in animals it produces 5-HT2A-mediated behaviors and serves as a training drug in drug-discrimination studies, with repeated dosing inducing tolerance accompanied by adaptation of cortical 5-HT2A and glutamate receptor binding. It is metabolized in part by CYP2D6 and, owing to its high potency, is commonly distributed on blotter. Its marathon duration, strong stimulant and body load, and pronounced vasoconstriction make it one of the riskier classic psychedelics.
DOC (4-chloro-2,5-dimethoxyamphetamine) is a potent, very long-acting psychedelic amphetamine of the DOx family, bearing a chlorine at the 4 position. It acts as a 5-HT2A serotonin receptor agonist, with the shared 2,5-dimethoxy motif underpinning its receptor activity, and produces a long, sharply visual psychedelic state with a strong stimulant edge; in rodent studies it has shown rewarding and reinforcing effects. Like other DOx compounds it is metabolized partly by CYP2D6 and carries pronounced vasoconstriction and a marathon duration. Fatal intoxications have been reported, and interpreting blood concentrations in such cases is complicated by its high potency and the very low concentrations involved.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
partial agonist
partial agonist
agonist
agonist
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.