Bupropion vs Venlafaxine

Bupropion is an atypical antidepressant of the aminoketone class that works mainly as a norepinephrine-dopamine reuptake inhibitor. It is used to treat major depressive disorder and seasonal affective disorder and, under a separate brand, as an aid to quitting smoking; it is also part of a combination weight-loss product. Unlike many antidepressants it has little direct effect on serotonin and rarely causes sexual dysfunction or weight gain.

effects

Dopamine, Norepinephrine

targets

Dopamine transporter (DAT), Norepinephrine transporter (NET), Nicotinic ACh receptors (a3b2, a4b2, a7)

suppliers

2 outlets

Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) used for major depressive disorder and several anxiety disorders, and available in immediate-release and extended-release forms. It is distinguished by an ascending dose-response relationship: at low doses it behaves much like a selective serotonin reuptake inhibitor, while progressively higher doses recruit norepinephrine reuptake inhibition, which contributes both to added efficacy and to dose-dependent increases in blood pressure. Beyond monoamine transport, preclinical work implicates sigma-1 receptor modulation in its antidepressant action, and the drug is widely repurposed as an effective nonhormonal treatment for menopausal and cancer-therapy-related hot flashes. Network meta-analyses place it among the more efficacious antidepressants, although tolerability, cardiovascular effects in overdose, and a pronounced discontinuation syndrome temper its use.

effects

serotonin reuptake, norepinephrine reuptake, Mood, Anxiety

targets

Serotonin transporter (SERT), Norepinephrine transporter (NET), Dopamine transporter (DAT), CYP2D6 enzyme +1 more

evidence

Strong evidence

suppliers

2 outlets