Loading…
for educational and safety purposes
Aniracetam and Phenylpiracetam both come up in the same conversations; they overlap on Acetylcholine. Aniracetam: Aniracetam is a fat-soluble member of the racetam family and one of the original ampakines, a positive allosteric modulator of AMPA-type glutamate receptors used as a cognition enhancer. Phenylpiracetam: Phenylpiracetam (phenotropil, carphedon) is a phenylated derivative of piracetam, developed in Russia and used clinically as a nootropic, with reported effects on focus, physical endurance, and tolerance to cold and fatigue.
Aniracetam is a fat-soluble member of the racetam family and one of the original ampakines, a positive allosteric modulator of AMPA-type glutamate receptors used as a cognition enhancer. By slowing the desensitization of these excitatory receptors it strengthens the synaptic transmission tied to learning and memory, and it has been used clinically abroad for cognitive symptoms after stroke and in dementia. Its principal metabolite, 2-pyrrolidinone, has been reported to produce a longer-lasting enhancement of AMPA-receptor function through a CaMKII-dependent pathway. It is also noted for anxiolytic and mood effects in animal models.
Phenylpiracetam (phenotropil, carphedon) is a phenylated derivative of piracetam, developed in Russia and used clinically as a nootropic, with reported effects on focus, physical endurance, and tolerance to cold and fatigue. The added phenyl group makes it considerably more potent than the parent racetam and confers a distinct mechanism, selective inhibition of the dopamine transporter, which is thought to underlie its stimulant-like, motivating properties. It was among the first cognitive enhancers prohibited in competitive sport, having been banned by anti-doping authorities in 1998.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
positive modulator
increases
mild agonist
modulates
agonist
inhibits (R-enantiomer)
enhances
mostly lost vs piracetam
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.
easiest to source: Phenylpiracetam is currently listed by more trusted vendors (3), so it's the simpler one to get hold of. for effects and safety, read each full entry; this is educational, not medical advice.