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for educational and safety purposes
Amantadine and Selegiline both come up in the same conversations. Amantadine: Amantadine is an adamantane-derived drug that was first introduced in the 1960s as an antiviral agent against influenza A and later found, by chance, to relieve the symptoms of Parkinson's disease. Selegiline: Selegiline, also known as L-deprenyl, is a selective and irreversible inhibitor of monoamine oxidase B (MAO-B), used in the treatment of Parkinson's disease and, in a transdermal patch form, of major depressive disorder.
Amantadine is an adamantane-derived drug that was first introduced in the 1960s as an antiviral agent against influenza A and later found, by chance, to relieve the symptoms of Parkinson's disease. Today it is used mainly in neurology, particularly to treat the involuntary movements (dyskinesias) that can arise from long-term levodopa therapy, while its role against influenza has largely disappeared because of viral resistance. It acts through a combination of dopaminergic and glutamatergic effects on the brain [1][2].
Selegiline, also known as L-deprenyl, is a selective and irreversible inhibitor of monoamine oxidase B (MAO-B), used in the treatment of Parkinson's disease and, in a transdermal patch form, of major depressive disorder. At low doses it selectively spares MAO-A, which avoids the dietary tyramine restrictions required by older monoamine oxidase inhibitors, though this selectivity is lost at higher doses. It is marketed under names including Eldepryl, Zelapar, and, as a skin patch, Emsam.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
blocks
antagonist
modulates
antagonist
irreversible inhibitor
inhibits
protects neurons
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.