AL-LAD vs PRO-LAD

AL-LAD (6-allyl-6-nor-LSD) is a lysergamide psychedelic closely related to LSD, differing by replacement of the N6 methyl group with an allyl group. Like other serotonergic hallucinogens it acts primarily through agonism at the 5-HT2A receptor, and in the mouse head-twitch response assay it produces the characteristic inverted U-shaped dose-response curve, proving only slightly less potent than LSD itself. Users describe strongly visual, colorful effects with a duration comparable to LSD but often somewhat shorter and milder in strength and comedown. Analytical and metabolic studies have detailed its structure, biotransformation, and its acylated prodrug forms such as 1P-AL-LAD and 1cP-AL-LAD, which are hydrolyzed to AL-LAD in the body. A published case of fatal ventricular dysrhythmia associated with its use indicates that, despite its reputation as a gentler LSD analogue, it is not without cardiovascular risk.

effects

Serotonin

targets

5-HT2A receptor, 5-HT2C receptor, 5-HT1A receptor

suppliers

reference only

PRO-LAD is a lysergamide analog of lysergic acid diethylamide (LSD) in which one of the N,N-diethyl substituents is replaced by an n-propyl group. Like LSD it acts primarily as an agonist at the 5-HT2A serotonin receptor, the target that mediates the classic serotonergic psychedelic experience, and it also interacts broadly with other serotonin, dopamine, and adrenergic receptors characteristic of the lysergamide class. Reports place its potency in a range roughly comparable to LSD, producing a qualitatively similar visual and cognitive psychedelic state. Direct pharmacological data on PRO-LAD itself remain sparse; most available evidence comes from systematic studies of closely related N-substituted lysergamides, which are typically characterized in vitro and through the rodent head-twitch response as a behavioral proxy for 5-HT2A activation.

effects

Serotonin

targets

5-HT2A receptor, 5-HT2C receptor, 5-HT1A receptor

suppliers

reference only