5-MeO-DiPT vs 5-MeO-MiPT

5-MeO-DiPT (5-methoxy-N,N-diisopropyltryptamine), popularly called "Foxy," is a synthetic tryptamine combining a 5-methoxy group with two isopropyl side-chain substituents. Microdialysis studies indicate it acts through dual mechanisms, inhibiting the serotonin transporter while simultaneously stimulating 5-HT1A autoreceptors, so that its serotonin-elevating effect is self-limited; it also raises prefrontal dopamine and, like other tryptamine hallucinogens, drives a 5-HT2A-dependent head-twitch response. Users report a strongly physical, sometimes entactogenic experience with notable body load and nausea. Animal studies of repeated adolescent exposure describe lasting changes in monoamine neurotransmission, oxidative DNA damage and impaired learning, underscoring its unpredictable and potentially neurotoxic profile.

effects

Serotonin

targets

5-HT2A receptor, 5-HT1A receptor, 5-HT2C receptor

suppliers

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5-MeO-MiPT (5-methoxy-N-methyl-N-isopropyltryptamine), nicknamed "Moxy," is a synthetic tryptamine carrying a 5-methoxy group with methyl and isopropyl substituents on the amine. It is presumed to act as a serotonergic hallucinogen at 5-HT2A receptors, and preclinical characterization shows dose-dependent inhibition of sensorimotor and prepulse-inhibition responses together with impaired motor activity and cardiorespiratory changes at high doses. In silico modeling indicates a toxicokinetic profile resembling 5-MeO-DiPT and DMT, with metabolism proceeding largely via O-demethylation and hydroxylation. Users describe pronounced tactile and bodily effects with a moderate visual component; documented human intoxication cases mirror the effects observed in animal models.

effects

Serotonin

targets

5-HT2A receptor, 5-HT1A receptor

suppliers

reference only