2C-T-2 vs 2C-T-7

2C-T-2 is a sulfur-containing member of the 2C-T subfamily of psychedelic phenethylamines, bearing an ethylthio group at the 4 position of the 2,5-dimethoxyphenethylamine scaffold. Like related 4-thio-substituted phenylalkylamines, it binds with nanomolar affinity to 5-HT2A, 5-HT2B, and 5-HT2C receptors and behaves as a partial agonist at 5-HT2A, the interaction generally held to mediate its psychedelic effects; in mouse head-twitch assays, extension of the 4-alkylthio chain increases potency. In vitro work also shows that 2C-T compounds interact with human monoamine oxidases, consistent with the recognized and potentially serious hazard of combining them with MAO inhibitors. It is characterized by slow onset, long duration, and a pronounced body load.

effects

Serotonin

targets

5-HT2A receptor, 5-HT2C receptor

suppliers

reference only

2C-T-7 is a sulfur-containing member of the 2C family of psychedelic phenethylamines, bearing a propylthio group at the 4 position. It acts primarily as a partial agonist at the 5-HT2A serotonin receptor, to which it and related 4-thio compounds bind with nanomolar affinity; in rodents it produces hallucinogen-like behaviors such as the head-twitch response and drug-discrimination cues characteristic of 5-HT2A agonists. Repeated dosing induces tolerance and cross-tolerance with other phenethylamine hallucinogens, and in vitro data indicate interaction with monoamine oxidases. Sometimes marketed as 'Blue Mystic,' it carries a rougher safety reputation than simpler 2C compounds; several deaths, some confirmed by postmortem toxicology, have been linked to it, particularly at high doses or when insufflated.

effects

Serotonin

targets

5-HT2A receptor, 5-HT2C receptor

suppliers

reference only