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for educational and safety purposes
1cP-LSD and 1V-LSD both come up in the same conversations; they overlap on Serotonin. 1cP-LSD: 1cP-LSD (1-cyclopropanoyl-LSD) is a widely distributed lysergamide bearing a cyclopropylcarbonyl group on the indole nitrogen of LSD. 1V-LSD: 1V-LSD (1-valeroyl-LSD), nicknamed "Valerie," is an N1-acylated lysergamide that can be regarded as a higher homolog of ALD-52, 1P-LSD, and 1B-LSD, marketed as a research chemical.
1cP-LSD (1-cyclopropanoyl-LSD) is a widely distributed lysergamide bearing a cyclopropylcarbonyl group on the indole nitrogen of LSD. Incubation with human serum generates LSD, indicating that it acts as a prodrug in vivo, and it induces the LSD-like head-twitch response in mice with a median effective dose comparable to 1P-LSD; the liberated LSD produces the classic serotonergic psychedelic experience through 5-HT2A receptor agonism. Because of its close correspondence to LSD, it has become one of the most popular legal-grey lysergamides and has even been the subject of exploratory low-dose veterinary studies examining anxiety and welfare in dogs. Analytical, metabolic, and in silico toxicological investigations have characterized its detection, stability, and predicted hazard profile.
1V-LSD (1-valeroyl-LSD), nicknamed "Valerie," is an N1-acylated lysergamide that can be regarded as a higher homolog of ALD-52, 1P-LSD, and 1B-LSD, marketed as a research chemical. In the mouse head-twitch response it acts as a dose-dependent psychedelic with a median effective dose of about 373 nmol/kg, roughly one third the potency of LSD, and like related N1-acyl lysergamides it is believed to be hydrolyzed in vivo to LSD, functioning as a prodrug that engages the 5-HT2A receptor. It has been characterized by extensive mass spectrometry, chromatography, and spectroscopy, and has been identified in seized blotter products in Japan. In silico toxicology has additionally flagged the strongest predicted hERG channel inhibition of its series, suggesting comparatively higher theoretical proarrhythmic potential.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
partial agonist (via LSD)
partial agonist (via LSD)
agonist
agonist
agonist
partial agonist
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.