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for educational and safety purposes
1cP-LSD and ALD-52 both come up in the same conversations; they overlap on Serotonin. 1cP-LSD: 1cP-LSD (1-cyclopropanoyl-LSD) is a widely distributed lysergamide bearing a cyclopropylcarbonyl group on the indole nitrogen of LSD. ALD-52: ALD-52 (1-acetyl-LSD) is the 1-acetyl derivative of LSD, historically associated with the "Orange Sunshine" acid of the 1960s and one of the earliest known N-acylated lysergamides.
1cP-LSD (1-cyclopropanoyl-LSD) is a widely distributed lysergamide bearing a cyclopropylcarbonyl group on the indole nitrogen of LSD. Incubation with human serum generates LSD, indicating that it acts as a prodrug in vivo, and it induces the LSD-like head-twitch response in mice with a median effective dose comparable to 1P-LSD; the liberated LSD produces the classic serotonergic psychedelic experience through 5-HT2A receptor agonism. Because of its close correspondence to LSD, it has become one of the most popular legal-grey lysergamides and has even been the subject of exploratory low-dose veterinary studies examining anxiety and welfare in dogs. Analytical, metabolic, and in silico toxicological investigations have characterized its detection, stability, and predicted hazard profile.
ALD-52 (1-acetyl-LSD) is the 1-acetyl derivative of LSD, historically associated with the "Orange Sunshine" acid of the 1960s and one of the earliest known N-acylated lysergamides. Although 1-acyl substitution reduces affinity and efficacy at the 5-HT2A receptor by one to two orders of magnitude relative to LSD, pharmacological studies show that ALD-52 is rapidly and efficiently deacetylated in vivo to yield high plasma concentrations of LSD, supporting its classification as a prodrug. Consistent with this, it induces the 5-HT2A-mediated head-twitch response in mice with relatively high potency and produces a classic serotonergic psychedelic experience in humans of roughly LSD-like strength. It has re-emerged as a research chemical alongside related acyl derivatives such as 1P-LSD and 1cP-LSD, and in silico toxicology work has begun to profile its potential genotoxic and cardiopulmonary liabilities.
both fingerprints on one instrument; where the marks line up the two compounds work the same lever, where a slot goes dark only one of them touches it. read straight from each entry's affinity table; nothing here is invented.
partial agonist (via LSD)
partial agonist (via LSD)
agonist
agonist
agonist
partial agonist
strengths are the entries' qualitative ratings (strong / moderate / weak); Ki and EC50 figures appear where an entry records them.