Respiratory System: nootropics and compounds | sci-wiki

Bronchogen

Bronchogen is a synthetic tetrapeptide from the Khavinson family of tissue-specific peptide bioregulators, built from the amino acid composition of a bronchial mucosa polypeptide complex and aimed at the bronchopulmonary system [3][10]. It is normally written Ala-Glu-Asp-Leu, and it is not Chonluten, which is the tripeptide Glu-Asp-Gly drawn from the same complex. The research file is coherent and entirely preclinical; seventeen papers, no human study of any design, and no independent replication of the respiratory claim outside the originating research network.

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Peptide

Chonluten

Chonluten is a synthetic short peptide bioregulator derived from bronchial tissue, part of the celebrated Russian family of tissue-specific peptides developed for respiratory and immune support. It has been shown to calm inflammatory signaling in immune cells, reducing production of TNF and IL-6. For those focused on lung health, inflammation balance, and healthy aging, Chonluten is a distinctive and targeted peptide.

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Antiviral

Oseltamivir

Oseltamivir is an antiviral medication of the neuraminidase inhibitor class, used to treat and to help prevent influenza caused by type A and type B viruses. Taken by mouth as a prodrug, it is converted in the body to its active form, oseltamivir carboxylate, which blocks the influenza enzyme neuraminidase and so hinders the release and spread of new virus particles. Marketed under the brand name Tamiflu and approved in 1999, it is most useful when started within the first day or two of symptoms, and the size of its benefit, particularly for otherwise healthy people, has been the subject of considerable debate.

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Respiratory

Oxymetazoline

Oxymetazoline is a topical sympathomimetic decongestant and vasoconstrictor of the imidazoline class. Acting mainly as an agonist at alpha-adrenergic receptors, it narrows blood vessels in the lining of the nose and eye and is widely sold over the counter to relieve nasal congestion. It is also used in prescription formulations for facial redness in rosacea and for a drooping eyelid, and prolonged nasal use can cause rebound congestion.

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Respiratory

Dyphylline

Dyphylline is a xanthine-derivative bronchodilator that relaxes airway smooth muscle through nonselective phosphodiesterase inhibition and weak adenosine-receptor antagonism. Chemically 7-(2,3-dihydroxypropyl)-1,3-dimethylxanthine, it is a distinct synthetic methylxanthine rather than a theophylline salt, and unlike theophylline it is not metabolized to theophylline in the body but is instead cleared largely unchanged by the kidneys. Marketed for decades under names such as Dilor and Lufyllin (often combined with the expectorant guaifenesin), it is an FDA-approved agent used for the symptomatic relief of bronchospasm in asthma, chronic bronchitis, and chronic obstructive pulmonary disease. Compared with theophylline it is a somewhat weaker bronchodilator on a milligram basis but carries a wider tolerability margin, a shorter half-life, and far fewer drug and smoking interactions because it bypasses hepatic CYP1A2 metabolism. More recent laboratory work has explored repurposing dyphylline as a coronavirus main-protease inhibitor and as a cAMP-raising activator of dormant ovarian follicles.

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