PPAR-gamma

Every compound in the sci-wiki that affects ppar-gamma; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

2 sourced · 1 reference

←ppar-gamma3/3

Antidiabetic

Pioglitazone

Pioglitazone is an oral antidiabetic medicine of the thiazolidinedione class, used to improve blood sugar control in type 2 diabetes. Marketed as Actos, it works as an insulin sensitizer, activating a nuclear receptor called PPAR-gamma to make the body's tissues respond better to insulin. Effective at lowering blood glucose and with additional effects on fat and the liver, it is nonetheless used carefully because of side effects that include fluid retention, weight gain, and a debated association with bladder cancer.

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Blend

Pioglitazone + Metformin

Pioglitazone plus metformin is a fixed-dose combination tablet that unites two oral diabetes medicines with complementary actions: pioglitazone, a thiazolidinedione that makes tissues more sensitive to insulin, and metformin, a biguanide that mainly reduces the amount of glucose released by the liver. It is used to improve blood sugar control in adults with type 2 diabetes whose condition is not adequately managed on metformin alone. Combining the two drugs in a single pill is intended to lower blood sugar more fully while simplifying treatment, and it is marketed under names such as ACTOplus Met and Competact.

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reference shelf; no outlet carries these yet

Cannabinoid

Tetrahydrocannabinolic acid

Tetrahydrocannabinolic acid (THCA) is the non-intoxicating acidic cannabinoid that predominates in living and freshly harvested Cannabis sativa, where it can account for the large majority of the plant's total THC content [2]. It is the direct biosynthetic precursor of Δ9-tetrahydrocannabinol (THC): heating, aging, smoking, or vaporizing drives a decarboxylation reaction that strips off a carboxyl group and converts THCA into psychoactive THC, which is why raw, unheated cannabis does not produce a high [2][8]. Unlike THC, THCA binds the CB1 receptor only weakly, yet it is a comparatively potent agonist of the nuclear receptor PPAR-gamma and shows anti-inflammatory, neuroprotective, and anti-emetic activity in preclinical models [1][3][4]. Human evidence remains limited, and much of the interest in THCA centers on raw-cannabis juicing and non-heated preparations [7].

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