pituitary

Every compound in the sci-wiki that affects pituitary; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Dopaminergic

Bromocriptine

Bromocriptine is a dopamine receptor agonist derived from ergot, acting mainly at the dopamine D2 receptor. It is used to treat conditions linked to excess prolactin, such as prolactinomas and related infertility, as well as Parkinson disease, acromegaly, and, in a quick-release form, type 2 diabetes. Discovered by Sandoz in the 1960s, it was approved for medical use in the 1970s.

2 outlets

Dopaminergic

Cabergoline

Cabergoline is a long-acting, ergot-derived dopamine agonist that acts mainly at the dopamine D2 receptor. It is used chiefly to treat conditions of excess prolactin, especially prolactin-secreting pituitary tumors (prolactinomas), and is also used in Parkinson disease and acromegaly. Because of its long duration of action it is usually taken only once or twice a week.

2 outlets

Hormone

Elagolix

Elagolix is an orally active, non-peptide antagonist of the gonadotropin-releasing hormone (GnRH) receptor. By suppressing the ovaries' production of estrogen and progesterone, it is used to manage moderate to severe pain from endometriosis and, in combination with hormonal add-back therapy, to control heavy menstrual bleeding caused by uterine fibroids. It is taken as a tablet and is marketed under brand names including Orilissa.

1 outlet