lipid metabolism: nootropics and compounds | sci-wiki

Fenofibrate

Fenofibrate is a lipid-lowering medication of the fibrate class, used mainly to reduce high triglyceride levels and to manage mixed dyslipidemia. It is a prodrug that the body converts to its active form, fenofibric acid, which switches on a receptor called PPAR-alpha to change how the body handles fats. Sold under brand names such as Tricor, it is taken by mouth and is often combined with a statin.

1 outlet

Supplement

Icosapent Ethyl

Icosapent ethyl is a prescription omega-3 medication, the ethyl ester of eicosapentaenoic acid (EPA), a fatty acid found in fish oil. Unlike ordinary fish-oil supplements it is a highly purified form containing only EPA and no DHA. Sold under the brand Vascepa, it is used to lower very high triglycerides and, in people already on statins, to reduce the risk of cardiovascular events.

1 outlet

Supplement

1-MNA

1-Methylnicotinamide (1-MNA) is an endogenous metabolite of nicotinamide produced by the enzyme nicotinamide N-methyltransferase (NNMT), and it sits within the nicotinamide and NAD+ salvage pathway. Long regarded as a biologically inert excretory product, it is now recognised as a vasoprotective, anti-thrombotic and anti-inflammatory agent that stimulates endothelial release of prostacyclin (PGI2) and nitric oxide [1][2]. It is marketed as a metabolic and longevity-oriented supplement.

reference

PPAR Modulator

Aleglitazar

Aleglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that was developed by Hoffmann-La Roche as an oral treatment for type 2 diabetes. Its large Phase III cardiovascular outcomes trial (AleCardio) was halted early for safety signals and lack of efficacy, and all development was discontinued in 2013.

reference

Thyroid

ASC41

ASC41 is an investigational oral prodrug developed by Gannex, a subsidiary of Ascletis Pharma, for non-alcoholic steatohepatitis (NASH, increasingly called MASH). The liver converts it into ASC41-A, a selective agonist of thyroid hormone receptor beta (THR-beta).

reference

Lipid-Lowering

Avasimibe

Avasimibe is an investigational acyl-CoA cholesterol acyltransferase (ACAT) inhibitor that was studied as a lipid-lowering and anti-atherosclerotic agent.

reference

PPAR Modulator

Oleoylethanolamide

Oleoylethanolamide (OEA) is a naturally occurring lipid molecule that acts as a satiety signal in the body. It is the ethanolamide of oleic acid, a member of the fatty acid ethanolamide family that also includes the endocannabinoid anandamide, though OEA works through different pathways. Produced in the small intestine in response to eating fat, it reduces appetite and food intake mainly by activating the nuclear receptor PPAR-alpha. It has been studied extensively in relation to feeding, body weight, and obesity, and is sold as a dietary supplement.

reference