Glucose metabolism

Every compound in the sci-wiki that affects glucose metabolism; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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←glucose metabolism2/2

Mitochondrial

DADA

DADA is diisopropylamine dichloroacetate, an old liver drug sold in Japan for decades as Liverall and also sold in the West under the discredited "vitamin B15" or pangamic acid label; it is a simple salt that separates in the body into diisopropylamine and dichloroacetate. The dichloroacetate half blocks an enzyme called pyruvate dehydrogenase kinase, which pushes cells away from making lactate and toward burning fuel in the mitochondria; that single mechanism is why nearly all recent work on it is cancer and immune metabolism research in mice and cell dishes. Human evidence is thin; the only controlled human trial found is a 2005 Chinese study in fatty liver disease that compared 60 mg and 120 mg per day against each other with no placebo group, so it cannot show the drug beats doing nothing. It is not a dopamine drug, has no reported activity at dopamine receptors, and no study of any kind was found testing it for memory, mood, focus, or athletic performance.

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Terpene

Ursolic Acid

Ursolic acid is a pentacyclic triterpenoid found in the waxy peel of apples and in herbs like rosemary, basil, and holy basil. In rodents it enhances skeletal muscle IGF-1/insulin signaling through Akt, blunts atrophy genes, increases brown fat, and improves glucose tolerance. It also has broad anti-inflammatory and antioxidant activity in cell and animal work. Human data are small and mixed, and oral bioavailability is genuinely poor.

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