Estrogen: nootropics and compounds | sci-wiki

Arimidex

Arimidex is a brand name for anastrozole, a nonsteroidal aromatase inhibitor used mainly to treat hormone-receptor-positive breast cancer in postmenopausal women. By blocking the aromatase enzyme it sharply lowers the body's estrogen, slowing cancers that depend on estrogen to grow, and it is used as adjuvant therapy after surgery, for advanced disease, and, as shown in the IBIS-II trial, for prevention in high-risk women. Its common side effects, including joint pain, hot flashes, and bone thinning, are direct consequences of that profound estrogen suppression, which is also the basis of concern about effects on cognition.

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Hormone

Arimistane

Arimistane (androsta-3,5-diene-7,17-dione) is a steroidal aromatase inhibitor sold in bodybuilding supplements as an estrogen-control and post-cycle agent, structurally an androstadienedione and a known degradation product of 7-keto-DHEA. It is designed to blunt the conversion of androgens to estrogen by inhibiting the aromatase enzyme, with the aim of supporting testosterone and reducing estrogenic side effects. Human data are limited almost entirely to anti-doping detection studies, where it is a prohibited substance, and one controlled administration produced no measurable change in the urinary steroid profile, so its real hormonal impact remains poorly characterized [1][5].

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SERM

Tamoxifen

Tamoxifen is a selective estrogen receptor modulator (SERM) of the triphenylethylene family that acts as an estrogen blocker in some tissues and a weak estrogen mimic in others, best known as a hormone therapy for estrogen-receptor-positive breast cancer, used both to treat the disease and to lower its risk in high-risk people. Its pharmacology has two notable features: it is a prodrug, converted by the enzyme CYP2D6 into the far more potent active metabolite endoxifen, so common CYP2D6 variants and CYP2D6-inhibiting drugs such as paroxetine can reduce its effect, and its tissue-selective action explains why long-term use lowers breast-cancer mortality yet mildly raises endometrial-cancer risk. It appears on the World Health Organization's list of essential medicines.

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Adaptogen

Red Clover

Red clover (Trifolium pratense) is a short-lived perennial legume in the family Fabaceae, native to Europe, western Asia, and northwest Africa and widely grown as a forage and cover crop. Its flowers are a rich source of isoflavones, plant compounds that resemble estrogen, which has made red clover a popular dietary supplement for menopausal symptoms. Evidence for its benefit on hot flashes is mixed but points to a modest effect.

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