Cardiolipin

Every compound in the sci-wiki that affects cardiolipin; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

2 sourced · 1 reference

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Mitochondrial

SkQ1

SkQ1 is a mitochondria-targeted antioxidant, a synthetic compound built by attaching the plant antioxidant plastoquinone to a positively charged carrier that accumulates inside mitochondria. Developed by a Russian team led by Vladimir Skulachev, it is designed to neutralize reactive oxygen species at their main source and has been studied for aging and age-related conditions. Its best-known application is a dilute eye-drop formulation approved in Russia to treat dry eye syndrome.

1 outlet

Peptide

SS-31

SS-31, also known as elamipretide or Bendavia, is a cell-permeable mitochondria-targeting tetrapeptide that concentrates thousands-fold on the inner mitochondrial membrane by binding cardiolipin, the lipid that organizes the cristae and the electron-transport supercomplexes. Rather than acting as a general antioxidant, it restores cristae structure and bioenergetics in mitochondria damaged by ischemia, disease, or aging; in aged mouse muscle a single dose restored ATP production toward youthful levels within about an hour. It has been evaluated in clinical trials for primary mitochondrial diseases, heart failure, and age-related conditions.

6 outlets

reference shelf; no outlet carries these yet

Mitochondrial

SBT-272

SBT-272, given the international nonproprietary name bevemipretide, is a mitochondria-targeted peptidomimetic from Stealth BioTherapeutics that binds and stabilises cardiolipin, the signature phospholipid of the inner mitochondrial membrane [1]. In a hTDP-43 mouse model of ALS it restored mitochondrial structure, motility and respiratory function in diseased upper motor neurons, and sixty days of chronic dosing from an early symptomatic stage reduced astrogliosis, microgliosis and TDP-43 pathology in the motor cortex [1]. Reviews of the cardiolipin field describe it as a second-generation follow-on to elamipretide, redesigned for higher mitochondrial uptake and higher brain concentrations so that the same membrane mechanism can be tested in the central nervous system [2][6]. One primary peer-reviewed paper carries the entire preclinical case.

reference