aromatase enzyme

Every compound in the sci-wiki that affects aromatase enzyme; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Hormone

Exemestane

Exemestane is a steroidal aromatase inhibitor used chiefly to treat hormone-receptor-positive breast cancer in postmenopausal women. Sold under the brand name Aromasin, it lowers the body's estrogen supply by permanently inactivating aromatase, the enzyme that builds estrogen, and is taken as a once-daily oral tablet. It is also used off-label, mainly by men, to keep estrogen levels in check.

2 outlets

Hormone

Letrozole

Letrozole is a nonsteroidal aromatase inhibitor used chiefly to treat hormone receptor-positive breast cancer in postmenopausal women, working by suppressing the enzyme that manufactures estrogen and thereby slowing tumors that depend on it. In a notable paradox, the same estrogen suppression makes it an effective ovulation inducer, and because of its short half-life and monofollicular response it has become first-line for ovulation induction in polycystic ovary syndrome, where trials showed higher live-birth rates than clomiphene. It is also used off-label for endometriosis and is sold under the brand name Femara.

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