ADP receptor (P2Y12)

Every compound in the sci-wiki that affects adp receptor (p2y12); the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Anticoagulant

Clopidogrel

Clopidogrel is an oral antiplatelet medicine of the thienopyridine class that blocks the P2Y12 ADP receptor on platelets to make the blood less likely to clot [1][4]. Sold chiefly as Plavix, it is used to prevent heart attacks, strokes and other clot-related events in people with cardiovascular disease, and it is given alongside aspirin after coronary stent placement [1]. It is a prodrug that the liver must convert to its active form, and it appears on the World Health Organization's list of essential medicines [1][3].

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Clopidogrel + Aspirin

Clopidogrel plus aspirin is a combination of two antiplatelet drugs, known as dual antiplatelet therapy, used to make blood clots less likely in people at high cardiovascular risk [1][2][3]. The two medicines block platelet activation by different routes, so together they inhibit clotting more completely than either alone [1][2]. The combination is a standard treatment after coronary stent placement and in acute coronary syndromes, and short courses are used soon after a minor ischaemic stroke or transient ischaemic attack; the added protection comes at the cost of a higher bleeding risk [3][4][5].

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