Adipose tissue

Every compound in the sci-wiki that affects adipose tissue; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Peptide

AOD-9604

AOD-9604 is a synthetic peptide fragment of human growth hormone, corresponding to the C-terminal lipolytic domain (residues 176-191) with an added tyrosine, engineered to trigger fat breakdown without the blood-sugar and growth side effects of full growth hormone. In obese animals it reduced body weight and body fat and increased fat oxidation, while notably not impairing insulin sensitivity the way intact growth hormone does [1][3]. It is marketed as a fat-loss and recovery peptide, though it never gained approval as an anti-obesity drug and its human weight-loss data are limited [4].

6 outlets

Peptide

HGH Fragment 176-191

HGH Fragment 176-191 is the C-terminal lipolytic region of human growth hormone, isolated to keep the fat-burning action while shedding the hormone's growth and blood-sugar effects [1][2]. In obese animal models this fragment, developed clinically as AOD9604, reduces body weight and body fat, boosts fat oxidation, and stimulates lipolysis without raising blood glucose or acting through the growth hormone receptor [1][2][3]. It is this clean separation of fat metabolism from classic GH signaling that has made the fragment a focused research tool for obesity [3][4].

4 outlets

Terpene

Ursolic Acid

Ursolic acid is a pentacyclic triterpenoid found in the waxy peel of apples and in herbs like rosemary, basil, and holy basil. In rodents it enhances skeletal muscle IGF-1/insulin signaling through Akt, blunts atrophy genes, increases brown fat, and improves glucose tolerance. It also has broad anti-inflammatory and antioxidant activity in cell and animal work. Human data are small and mixed, and oral bioavailability is genuinely poor.

1 outlet